{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["44(7)"],"submitter":["Yang D"],"pubmed_abstract":["<h4>Background</h4>Coronavirus disease 2019 (COVID-19) has reached a pandemic level. Cardiac injury is not uncommon among COVID-19 patients. We sought to describe the electrocardiographic characteristics and to identify the prognostic significance of electrocardiography (ECG) findings of patients with COVID-19.<h4>Hypothesis</h4>ECG abnormality was associated with higher risk of death.<h4>Methods</h4>Consecutive patients with laboratory-confirmed COVID-19 and definite in-hospital outcome were retrospectively included. Demographic characteristics and clinical data were extracted from medical record. Initial ECGs at admission or during hospitalization were reviewed. A point-based scoring system of abnormal ECG findings was formed, in which 1 point each was assigned for the presence of axis deviation, arrhythmias, atrioventricular block, conduction tissue disease, QTc interval prolongation, pathological Q wave, ST-segment change, and T-wave change. The association between abnormal ECG scores and in-hospital mortality was assessed in multivariable Cox regression models.<h4>Results</h4>A total of 306 patients (mean 62.84 ± 14.69 years old, 48.0% male) were included. T-wave change (31.7%), QTc interval prolongation (30.1%), and arrhythmias (16.3%) were three most common found ECG abnormalities. 30 (9.80%) patients died during hospitalization. Abnormal ECG scores were significantly higher among non-survivors (median 2 points vs 1 point, p < 0.001). The risk of in-hospital death increased by a factor of 1.478 (HR 1.478, 95% CI 1.131-1.933, p = 0.004) after adjusted by age, comorbidities, cardiac injury and treatments.<h4>Conclusions</h4>ECG abnormality was common in patients admitted for COVID-19 and was associated with adverse in-hospital outcome. In-hospital mortality risk increased with increasing abnormal ECG scores."],"journal":["Clinical cardiology"],"pagination":["963-970"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8237010"],"repository":["biostudies-literature"],"pubmed_title":["The prognostic significance of electrocardiography findings in patients with coronavirus disease 2019: A retrospective study."],"pmcid":["PMC8237010"],"pubmed_authors":["Pan W","Zhang F","Li J","Tian G","Yang D","Li L","Deng H","Cheng Z","Fang Y","Gao P","Fan H","Cheng K","Fang Q","Yi C","Wu Y","Chen T"],"additional_accession":[]},"is_claimable":false,"name":"The prognostic significance of electrocardiography findings in patients with coronavirus disease 2019: A retrospective study.","description":"<h4>Background</h4>Coronavirus disease 2019 (COVID-19) has reached a pandemic level. Cardiac injury is not uncommon among COVID-19 patients. We sought to describe the electrocardiographic characteristics and to identify the prognostic significance of electrocardiography (ECG) findings of patients with COVID-19.<h4>Hypothesis</h4>ECG abnormality was associated with higher risk of death.<h4>Methods</h4>Consecutive patients with laboratory-confirmed COVID-19 and definite in-hospital outcome were retrospectively included. Demographic characteristics and clinical data were extracted from medical record. Initial ECGs at admission or during hospitalization were reviewed. A point-based scoring system of abnormal ECG findings was formed, in which 1 point each was assigned for the presence of axis deviation, arrhythmias, atrioventricular block, conduction tissue disease, QTc interval prolongation, pathological Q wave, ST-segment change, and T-wave change. The association between abnormal ECG scores and in-hospital mortality was assessed in multivariable Cox regression models.<h4>Results</h4>A total of 306 patients (mean 62.84 ± 14.69 years old, 48.0% male) were included. T-wave change (31.7%), QTc interval prolongation (30.1%), and arrhythmias (16.3%) were three most common found ECG abnormalities. 30 (9.80%) patients died during hospitalization. Abnormal ECG scores were significantly higher among non-survivors (median 2 points vs 1 point, p < 0.001). The risk of in-hospital death increased by a factor of 1.478 (HR 1.478, 95% CI 1.131-1.933, p = 0.004) after adjusted by age, comorbidities, cardiac injury and treatments.<h4>Conclusions</h4>ECG abnormality was common in patients admitted for COVID-19 and was associated with adverse in-hospital outcome. In-hospital mortality risk increased with increasing abnormal ECG scores.","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Jul","modification":"2022-02-10T18:55:48.529Z","creation":"2022-02-10T18:55:48.529Z"},"accession":"S-EPMC8237010","cross_references":{"pubmed":["33973673"],"doi":["10.1002/clc.23628"]}}