{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["7(6)"],"submitter":["Umezu T"],"funding":["Smoking Research Foundation"],"pubmed_abstract":["The present study used a binding assay to identify novel target biomolecules of <i>l</i>-menthol ([-]-menthol) that promote mouse ambulation. Among 88 different ligands to specific biomolecules examined, 0.1 mM <i>l</i>-menthol inhibited the binding of 13 ligands with relatively high inhibition rates. The assays showed that <i>l</i>-menthol acts on calcium channels, sodium channels, γ-aminobutyric acid type A (GABA<sub>A</sub>) receptor, GABA transporter, dopamine transporter, dopamine D4 receptor, adenosine A2a receptor, α2A-adrenergic receptor, histamine H2 receptor, bombesin receptor, angiotensin AT1 receptor, vasopressin V2 receptor, and leukotriene B4 receptor over a similar concentration range. The inhibition constant (K<sub>i</sub>) for <i>l</i>-menthol inhibition of binding of [<su"],"journal":["Heliyon"],"pagination":["e07329"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8237303"],"repository":["biostudies-literature"],"pubmed_title":["Identification of novel target molecules of <i>l</i>-menthol."],"pmcid":["PMC8237303"],"pubmed_authors":["Umezu T"],"additional_accession":[]},"is_claimable":false,"name":"Identification of novel target molecules of <i>l</i>-menthol.","description":"The present study used a binding assay to identify novel target biomolecules of <i>l</i>-menthol ([-]-menthol) that promote mouse ambulation. Among 88 different ligands to specific biomolecules examined, 0.1 mM <i>l</i>-menthol inhibited the binding of 13 ligands with relatively high inhibition rates. The assays showed that <i>l</i>-menthol acts on calcium channels, sodium channels, γ-aminobutyric acid type A (GABA<sub>A</sub>) receptor, GABA transporter, dopamine transporter, dopamine D4 receptor, adenosine A2a receptor, α2A-adrenergic receptor, histamine H2 receptor, bombesin receptor, angiotensin AT1 receptor, vasopressin V2 receptor, and leukotriene B4 receptor over a similar concentration range. The inhibition constant (K<sub>i</sub>) for <i>l</i>-menthol inhibition of binding of [<su","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Jun","modification":"2026-05-09T07:59:18.975Z","creation":"2022-02-10T17:07:48.196Z"},"accession":"S-EPMC8237303","cross_references":{"pubmed":["34195432"],"doi":["10.1016/j.heliyon.2021.e07329"]}}