{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Hoshino Y"],"funding":["HHS | National Institutes of Health","Human Frontier Science Program","U.S. Department of Defense","NIAMS NIH HHS","Agouron Institute"],"pagination":["e2101276118"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8237579"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["118(25)"],"pubmed_abstract":["Steroids are components of the eukaryotic cellular membrane and have indispensable roles in the process of eukaryotic endocytosis by regulating membrane fluidity and permeability. In particular, steroids may have been a structural prerequisite for the acquisition of mitochondria via endocytosis during eukaryogenesis. While eukaryotes are inferred to have evolved from an archaeal lineage, there is little similarity between the eukaryotic and archaeal cellular membranes. As such, the evolution of eukaryotic cellular membranes has limited our understanding of eukaryogenesis. Despite evolving from archaea, the eukaryotic cellular membrane is essentially a fatty acid bacterial-type membrane, which implies a substantial bacterial contribution to the evolution of the eukaryotic cellular membrane."],"journal":["Proceedings of the National Academy of Sciences of the United States of America"],"pubmed_title":["Evolution of bacterial steroid biosynthesis and its impact on eukaryogenesis."],"pmcid":["PMC8237579"],"funding_grant_id":["R01AR069137","Postdoctoral fellowship","MURI W911NF-16-1-0372","R01 AR069137","RGP0041"],"pubmed_authors":["Gaucher EA","Hoshino Y"],"additional_accession":[]},"is_claimable":false,"name":"Evolution of bacterial steroid biosynthesis and its impact on eukaryogenesis.","description":"Steroids are components of the eukaryotic cellular membrane and have indispensable roles in the process of eukaryotic endocytosis by regulating membrane fluidity and permeability. In particular, steroids may have been a structural prerequisite for the acquisition of mitochondria via endocytosis during eukaryogenesis. While eukaryotes are inferred to have evolved from an archaeal lineage, there is little similarity between the eukaryotic and archaeal cellular membranes. As such, the evolution of eukaryotic cellular membranes has limited our understanding of eukaryogenesis. Despite evolving from archaea, the eukaryotic cellular membrane is essentially a fatty acid bacterial-type membrane, which implies a substantial bacterial contribution to the evolution of the eukaryotic cellular membrane.","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Jun","modification":"2026-05-09T07:30:46.376Z","creation":"2025-05-18T12:40:23.03Z"},"accession":"S-EPMC8237579","cross_references":{"pubmed":["34131078"],"doi":["10.1073/pnas.2101276118"]}}