{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Mezhibovsky E"],"funding":["NCCIH NIH HHS","National Institutes of Health"],"pagination":["675267"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8238044"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["8"],"pubmed_abstract":["A Western Diet (WD) low in fiber but high in fats and sugars contributes to obesity and non-alcoholic fatty liver disease (NAFLD). Supplementation with grape polyphenols (GPs) rich in B-type proanthocyanidins (PACs) can attenuate symptoms of cardiometabolic disease and alter the gut microbiota and its metabolites. We hypothesized that GP-mediated metabolic improvements would correlate with altered microbial metabolites such as short chain fatty acids (SCFAs). To more closely mimic a WD, C57BL/6J male mice were fed a low-fiber diet high in sucrose and butterfat along with 20% sucrose water to represent sugary beverages. This WD was supplemented with 1% GPs (WD-GP) to investigate the impact of GPs on energy balance, SCFA profile, and intestinal metabolism. Compared to WD-fed mice, the WD-GP "],"journal":["Frontiers in nutrition"],"pubmed_title":["Grape Polyphenols Attenuate Diet-Induced Obesity and Hepatic Steatosis in Mice in Association With Reduced Butyrate and Increased Markers of Intestinal Carbohydrate Oxidation."],"pmcid":["PMC8238044"],"funding_grant_id":["F31 AT010981","R01 AT010242"],"pubmed_authors":["Knowles KA","Duran RM","Sui K","Roopchand DE","He Q","Mezhibovsky E","Tveter KM"],"additional_accession":[]},"is_claimable":false,"name":"Grape Polyphenols Attenuate Diet-Induced Obesity and Hepatic Steatosis in Mice in Association With Reduced Butyrate and Increased Markers of Intestinal Carbohydrate Oxidation.","description":"A Western Diet (WD) low in fiber but high in fats and sugars contributes to obesity and non-alcoholic fatty liver disease (NAFLD). Supplementation with grape polyphenols (GPs) rich in B-type proanthocyanidins (PACs) can attenuate symptoms of cardiometabolic disease and alter the gut microbiota and its metabolites. We hypothesized that GP-mediated metabolic improvements would correlate with altered microbial metabolites such as short chain fatty acids (SCFAs). To more closely mimic a WD, C57BL/6J male mice were fed a low-fiber diet high in sucrose and butterfat along with 20% sucrose water to represent sugary beverages. This WD was supplemented with 1% GPs (WD-GP) to investigate the impact of GPs on energy balance, SCFA profile, and intestinal metabolism. Compared to WD-fed mice, the WD-GP ","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021","modification":"2026-05-09T07:25:30.937Z","creation":"2022-02-10T17:35:52.004Z"},"accession":"S-EPMC8238044","cross_references":{"pubmed":["34195217"],"doi":["10.3389/fnut.2021.675267"]}}