{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Beiriger A"],"funding":["National Center for Advancing Translational Sciences","NICHD NIH HHS","NCATS NIH HHS","National Science Foundation"],"pagination":["1293-1307"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8238524"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["529(7)"],"pubmed_abstract":["In vertebrate animals, motor and sensory efferent neurons carry information from the central nervous system (CNS) to peripheral targets. These two types of efferent systems sometimes bear a close resemblance, sharing common segmental organization, axon pathways, and chemical messengers. Here, we focus on the development of the octavolateral efferent neurons (OENs) and their interactions with the closely-related facial branchiomotor neurons (FBMNs) in zebrafish. Using live-imaging approaches, we investigate the birth, migration, and projection patterns of OENs. We find that OENs are born in two distinct groups: a group of rostral efferent neurons (RENs) that arises in the fourth segment, or rhombomere (r4), of the hindbrain and a group of caudal efferent neurons (CENs) that arises in r5. Both RENs and CENs then migrate posteriorly through the hindbrain between 18 and 48 hrs postfertilization, alongside the r4-derived FBMNs. Like the FBMNs, migration of the r4-derived RENs depends on function of the segmental identity gene hoxb1a; unlike the FBMNs, however, both OEN populations move independently of prickle1b. Further, we investigate whether the previously described \"pioneer\" neuron that leads FBMN migration through the hindbrain is an r4-derived FBMN/REN or an r5-derived CEN. Our experiments verify that the pioneer is an r4-derived neuron and reaffirm its role in leading FBMN migration across the r4/5 border. In contrast, the r5-derived CENs migrate independently of the pioneer. Together, these results indicate that the mechanisms OENs use to navigate the hindbrain differ significantly from those employed by FBMNs."],"journal":["The Journal of comparative neurology"],"pubmed_title":["Development and migration of the zebrafish rhombencephalic octavolateral efferent neurons."],"pmcid":["PMC8238524"],"funding_grant_id":["T32 HD055164","1528911","UL1 TR002389","5UL1TR002389","DGE‐1144082"],"pubmed_authors":["Beiriger A","Prince V","Singh N","Narayan S"],"additional_accession":[]},"is_claimable":false,"name":"Development and migration of the zebrafish rhombencephalic octavolateral efferent neurons.","description":"In vertebrate animals, motor and sensory efferent neurons carry information from the central nervous system (CNS) to peripheral targets. These two types of efferent systems sometimes bear a close resemblance, sharing common segmental organization, axon pathways, and chemical messengers. Here, we focus on the development of the octavolateral efferent neurons (OENs) and their interactions with the closely-related facial branchiomotor neurons (FBMNs) in zebrafish. Using live-imaging approaches, we investigate the birth, migration, and projection patterns of OENs. We find that OENs are born in two distinct groups: a group of rostral efferent neurons (RENs) that arises in the fourth segment, or rhombomere (r4), of the hindbrain and a group of caudal efferent neurons (CENs) that arises in r5. Both RENs and CENs then migrate posteriorly through the hindbrain between 18 and 48 hrs postfertilization, alongside the r4-derived FBMNs. Like the FBMNs, migration of the r4-derived RENs depends on function of the segmental identity gene hoxb1a; unlike the FBMNs, however, both OEN populations move independently of prickle1b. Further, we investigate whether the previously described \"pioneer\" neuron that leads FBMN migration through the hindbrain is an r4-derived FBMN/REN or an r5-derived CEN. Our experiments verify that the pioneer is an r4-derived neuron and reaffirm its role in leading FBMN migration across the r4/5 border. In contrast, the r5-derived CENs migrate independently of the pioneer. Together, these results indicate that the mechanisms OENs use to navigate the hindbrain differ significantly from those employed by FBMNs.","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 May","modification":"2025-06-01T03:29:14.445Z","creation":"2025-06-01T03:29:14.445Z"},"accession":"S-EPMC8238524","cross_references":{"pubmed":["32869305"],"doi":["10.1002/cne.25021"]}}