{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Hoover SE"],"funding":["NIDDK NIH HHS","National Institute of Diabetes and Digestive and Kidney Diseases","UAB","NHLBI NIH HHS"],"pagination":["nzab082"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8238660"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["5(6)"],"pubmed_abstract":["<h4>Background</h4>Short-term markers of successful visceral adipose tissue (VAT) loss are needed. Urinary F<sub>2</sub>-isoprostanes might serve as a marker for intensified lipid metabolism, whereas circulating IL-6 might stimulate fat oxidation and enhance mobilization of VAT.<h4>Objectives</h4>This pilot study was designed to explore the hypotheses that <i>1</i>) reduction in VAT is associated with increase in IL-6, and <i>2</i>) that increases in urinary F<sub>2</sub>-isoprostanes are associated with increases in IL-6 and reduction in VAT.<h4>Methods</h4>Eighteen participants (aged 60-75 y, BMI 30-40 kg/m<sup>2</sup>) were randomly assigned to either a very-low-carbohydrate diet (VLCD; <10:25:>65% energy from carbohydrate:protein:fat) or a low-fat diet (LFD; 55:25:20%) for 8 wk. Change"],"journal":["Current developments in nutrition"],"pubmed_title":["A Pilot Study of Associations Between Visceral Fat, IL-6, and Urinary F<sub>2</sub>-Isoprostanes in Older Adults Exposed to a Diet Intervention."],"pmcid":["PMC8238660"],"funding_grant_id":["P60DK079626","P30DK56336","P30 DK079626","P30 DK056336","T32HL105349","T32 HL105349"],"pubmed_authors":["Hoover SE","Spasojevic I","Gower BA","Goss AM","Il'yasova D","Fontaine KR"],"additional_accession":[]},"is_claimable":false,"name":"A Pilot Study of Associations Between Visceral Fat, IL-6, and Urinary F<sub>2</sub>-Isoprostanes in Older Adults Exposed to a Diet Intervention.","description":"<h4>Background</h4>Short-term markers of successful visceral adipose tissue (VAT) loss are needed. Urinary F<sub>2</sub>-isoprostanes might serve as a marker for intensified lipid metabolism, whereas circulating IL-6 might stimulate fat oxidation and enhance mobilization of VAT.<h4>Objectives</h4>This pilot study was designed to explore the hypotheses that <i>1</i>) reduction in VAT is associated with increase in IL-6, and <i>2</i>) that increases in urinary F<sub>2</sub>-isoprostanes are associated with increases in IL-6 and reduction in VAT.<h4>Methods</h4>Eighteen participants (aged 60-75 y, BMI 30-40 kg/m<sup>2</sup>) were randomly assigned to either a very-low-carbohydrate diet (VLCD; <10:25:>65% energy from carbohydrate:protein:fat) or a low-fat diet (LFD; 55:25:20%) for 8 wk. Change","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Jun","modification":"2026-05-08T04:25:53.707Z","creation":"2022-02-10T17:50:45.802Z"},"accession":"S-EPMC8238660","cross_references":{"pubmed":["34212125"],"doi":["10.1093/cdn/nzab082"]}}