biostudies-literatureHoover SENIDDK NIH HHSNational Institute of Diabetes and Digestive and Kidney DiseasesUABNHLBI NIH HHSnzab082https://www.ebi.ac.uk/biostudies/studies/S-EPMC8238660biostudies-literatureUnknown5(6)<h4>Background</h4>Short-term markers of successful visceral adipose tissue (VAT) loss are needed. Urinary F₂-isoprostanes might serve as a marker for intensified lipid metabolism, whereas circulating IL-6 might stimulate fat oxidation and enhance mobilization of VAT.<h4>Objectives</h4>This pilot study was designed to explore the hypotheses that <i>1</i>) reduction in VAT is associated with increase in IL-6, and <i>2</i>) that increases in urinary F₂-isoprostanes are associated with increases in IL-6 and reduction in VAT.<h4>Methods</h4>Eighteen participants (aged 60-75 y, BMI 30-40 kg/m²) were randomly assigned to either a very-low-carbohydrate diet (VLCD; <10:25:>65% energy from carbohydrate:protein:fat) or a low-fat diet (LFD; 55:25:20%) for 8 wk. ChangeCurrent developments in nutritionA Pilot Study of Associations Between Visceral Fat, IL-6, and Urinary F₂-Isoprostanes in Older Adults Exposed to a Diet Intervention.PMC8238660P60DK079626P30DK56336P30 DK079626P30 DK056336T32HL105349T32 HL105349Hoover SESpasojevic IGower BAGoss AMIl'yasova DFontaine KRfalseA Pilot Study of Associations Between Visceral Fat, IL-6, and Urinary F₂-Isoprostanes in Older Adults Exposed to a Diet Intervention.<h4>Background</h4>Short-term markers of successful visceral adipose tissue (VAT) loss are needed. Urinary F₂-isoprostanes might serve as a marker for intensified lipid metabolism, whereas circulating IL-6 might stimulate fat oxidation and enhance mobilization of VAT.<h4>Objectives</h4>This pilot study was designed to explore the hypotheses that <i>1</i>) reduction in VAT is associated with increase in IL-6, and <i>2</i>) that increases in urinary F₂-isoprostanes are associated with increases in IL-6 and reduction in VAT.<h4>Methods</h4>Eighteen participants (aged 60-75 y, BMI 30-40 kg/m²) were randomly assigned to either a very-low-carbohydrate diet (VLCD; <10:25:>65% energy from carbohydrate:protein:fat) or a low-fat diet (LFD; 55:25:20%) for 8 wk. Change2021-01-01T00:00:00Z2021 Jun2026-05-08T04:25:53.707Z2022-02-10T17:50:45.802ZS-EPMC82386603421212510.1093/cdn/nzab082