biostudies-literatureAmariglio RENIA NIH HHS257-262https://www.ebi.ac.uk/biostudies/studies/S-EPMC8240963biostudies-literatureUnknown8(3)<h4>Background</h4>Greater subjective cognitive changes on the Cognitive Function Index (CFI) was previously found to be associated with elevated amyloid (Aß) status in participants screening for the A4 Study, reported by study partners and the participants themselves. While the total score on the CFI related to amyloid for both sources respectively, potential differences in the specific types of cognitive changes reported by either participants or their study partners was not investigated.<h4>Objectives</h4>To determine the specific types of subjective cognitive changes endorsed by participants and their study partners that are associated with amyloid status in individuals screening for an AD prevention trial.<h4>Design, setting, participants</h4>Four thousand four hundred and eighty-six The journal of prevention of Alzheimer's diseaseItem-Level Investigation of Participant and Study Partner Report on the Cognitive Function Index from the A4 Study Screening Data.PMC8240963R01 AG047922U01 AG010483U24 AG057437R01 AG063689U19 AG010483K23 AG058805R01 AG061146R01 AG076634Marshall GAHoldridge KCSims JRRentz DMRaman RDonohue MCSikkes SAMGatchel JRJohnson KAGrill JDAisen PSAmariglio RESperling RABuckley RFSun CKYaari RfalseItem-Level Investigation of Participant and Study Partner Report on the Cognitive Function Index from the A4 Study Screening Data.<h4>Background</h4>Greater subjective cognitive changes on the Cognitive Function Index (CFI) was previously found to be associated with elevated amyloid (Aß) status in participants screening for the A4 Study, reported by study partners and the participants themselves. While the total score on the CFI related to amyloid for both sources respectively, potential differences in the specific types of cognitive changes reported by either participants or their study partners was not investigated.<h4>Objectives</h4>To determine the specific types of subjective cognitive changes endorsed by participants and their study partners that are associated with amyloid status in individuals screening for an AD prevention trial.<h4>Design, setting, participants</h4>Four thousand four hundred and eighty-six 2021-01-01T00:00:00Z20212026-06-01T16:45:50.575Z2026-05-19T03:06:57.857ZS-EPMC82409633410178110.14283/jpad.2021.8