biostudies-literatureHe MMAmerican Cancer SocietyDeutsche ForschungsgemeinschaftNational Natural Science Foundation of ChinaNCI NIH HHSNational Institutes of HealthWellcome TrustNatural Science Foundation of Jiangsu Province1867-1878https://www.ebi.ac.uk/biostudies/studies/S-EPMC8244830biostudies-literatureUnknown148(8)Evidence links the liver to development of colorectal cancer (CRC). However, it remains unknown how liver function may influence CRC risk in the general population. We conducted a prospective cohort study in the UK Biobank of 375 693 participants who provided blood samples in 2006 to 2010. Circulating levels of liver function markers (alanine transaminase [ALT], aspartate transaminase [AST], total bilirubin [TBIL], gamma glutamyltransferase [GGT], alkaline phosphatase [ALP], total protein [TP] and albumin [ALB]) were measured. Incident cancer cases were identified through linkage to the national cancer registry up to 2019. Repeated biomarker measurements were available from a subset of 11 320 participants who were re-assessed in 2012 to 2013. After a median follow-up of 10.0 years, we docuInternational journal of cancerCirculating liver function markers and colorectal cancer risk: A prospective cohort study in the UK Biobank.PMC8244830R00 CA215314BK20190083MRSG‐17‐220‐01‐NEC81973127DFG 426308975Lo CHPolychronidis GHe MMWang FWang KKnudsen MDWang LHang DFang ZSong MZhong RXu RHSmith SGfalseCirculating liver function markers and colorectal cancer risk: A prospective cohort study in the UK Biobank.Evidence links the liver to development of colorectal cancer (CRC). However, it remains unknown how liver function may influence CRC risk in the general population. We conducted a prospective cohort study in the UK Biobank of 375 693 participants who provided blood samples in 2006 to 2010. Circulating levels of liver function markers (alanine transaminase [ALT], aspartate transaminase [AST], total bilirubin [TBIL], gamma glutamyltransferase [GGT], alkaline phosphatase [ALP], total protein [TP] and albumin [ALB]) were measured. Incident cancer cases were identified through linkage to the national cancer registry up to 2019. Repeated biomarker measurements were available from a subset of 11 320 participants who were re-assessed in 2012 to 2013. After a median follow-up of 10.0 years, we docu2021-01-01T00:00:00Z2021 Apr2025-04-22T21:54:01.274Z2025-04-06T03:53:21.605ZS-EPMC82448303309195610.1002/ijc.33351