biostudies-literatureHummel SNational Institute of Environmental Health SciencesEunice Kennedy Shriver National Institute of Child Health and Human DevelopmentNCATS NIH HHSNational Institute of Diabetes and Digestive and Kidney DiseasesJuvenile Diabetes Research FoundationNIHGerman Federal Ministry of Education and ResearchNational Institute of Allergy and Infectious DiseasesNational Center for Advancing Translational Sciences Clinical and Translational ScienceGerman Center for Diabetes ResearchUniversity of FloridaNIDDK NIH HHSNLM NIH HHSUniversity of Colorado134-142https://www.ebi.ac.uk/biostudies/studies/S-EPMC8246624biostudies-literatureUnknown114(1)<h4>Background</h4>Breastfeeding has beneficial effects on numerous health outcomes.<h4>Objectives</h4>We investigated whether breastfeeding duration is associated with the development of early childhood autoimmunity, allergies, or obesity in a multinational prospective birth cohort.<h4>Methods</h4>Infants with genetic susceptibility for type 1 diabetes (n = 8676) were followed for the development of autoantibodies to islet autoantigens or transglutaminase, allergies, and for anthropometric measurements to a median age of 8.3 y (IQR: 2.8-10.2 y). Information on breastfeeding was collected at 3 mo of age and prospectively thereafter. A propensity score for longer breastfeeding was calculated from the variables that were likely to influence any or exclusive breastfeeding. The risks of develoThe American journal of clinical nutritionAssociations of breastfeeding with childhood autoimmunity, allergies, and overweight: The Environmental Determinants of Diabetes in the Young (TEDDY) study.PMC8246624U01 DK63863U01 DK63861UC4 DK117483UL1 TR002535U01 DK063821U01 DK063865U01 DK63821U01 DK63865U01 DK063863UC4 DK63821UC4 DK63865U01 DK63829UC4 DK112243UC4 DK63861UC4 DK63863UL1 TR000064FKZ 01KX1818UC4 DK95300UC4 DK063821U01 DK63790UC4 DK063865UC4 DK63829U01 DK63836UC4 DK100238UC4 DK106955FKZ 01EA1905UC4 DK63836HHSN267200700014CLynch KUusitalo UHagopian WAAronsson CATEDDY Study GroupRewers MJVirtanen SMLernmark AWeiß AKrischer JPBeyerlein AShe JXZiegler AGAgardh DAkolkar BHummel SKoletzko SVehik KBonifacio EToppari JNorris JMfalseAssociations of breastfeeding with childhood autoimmunity, allergies, and overweight: The Environmental Determinants of Diabetes in the Young (TEDDY) study.<h4>Background</h4>Breastfeeding has beneficial effects on numerous health outcomes.<h4>Objectives</h4>We investigated whether breastfeeding duration is associated with the development of early childhood autoimmunity, allergies, or obesity in a multinational prospective birth cohort.<h4>Methods</h4>Infants with genetic susceptibility for type 1 diabetes (n = 8676) were followed for the development of autoantibodies to islet autoantigens or transglutaminase, allergies, and for anthropometric measurements to a median age of 8.3 y (IQR: 2.8-10.2 y). Information on breastfeeding was collected at 3 mo of age and prospectively thereafter. A propensity score for longer breastfeeding was calculated from the variables that were likely to influence any or exclusive breastfeeding. The risks of develo2021-01-01T00:00:00Z2021 Jul2025-04-05T10:03:12.378Z2025-04-05T10:03:12.378ZS-EPMC82466243383194410.1093/ajcn/nqab065