biostudies-literatureUnknown11Zhang H<h4>Background</h4>The use of opioids in patients with metastatic pancreatic ductal adenocarcinoma (PDAC) is associated with shorter survival and not dependent on the expression of the mu-opioid receptor (MOR). The role of opioid use and MOR expression in stage I-III PDAC has not been investigated.<h4>Methods</h4>We conducted retrospective study in patients with stage I-III PDAC. MOR expression and <i>OPRM1</i> gene expression in tumour tissue and non-tumour tissue was measured. Primary endpoints were overall survival (OS) and disease-free survival (DFS). Secondary endpoints included perineural invasion, intraoperative sufentanil consumption, and length of stay. We performed a subgroup group analysis to evaluate the interaction between levels of MOR expression, amount of opioids use (high Frontiers in oncology686877https://www.ebi.ac.uk/biostudies/studies/S-EPMC8249918biostudies-literatureAssociation of Mu-Opioid Receptor(MOR) Expression and Opioids Requirement With Survival in Patients With Stage I-III Pancreatic Ductal Adenocarcinoma.PMC8249918Zhang HQu MMiao CChen WGorur ACata JPSun ZfalseAssociation of Mu-Opioid Receptor(MOR) Expression and Opioids Requirement With Survival in Patients With Stage I-III Pancreatic Ductal Adenocarcinoma.<h4>Background</h4>The use of opioids in patients with metastatic pancreatic ductal adenocarcinoma (PDAC) is associated with shorter survival and not dependent on the expression of the mu-opioid receptor (MOR). The role of opioid use and MOR expression in stage I-III PDAC has not been investigated.<h4>Methods</h4>We conducted retrospective study in patients with stage I-III PDAC. MOR expression and <i>OPRM1</i> gene expression in tumour tissue and non-tumour tissue was measured. Primary endpoints were overall survival (OS) and disease-free survival (DFS). Secondary endpoints included perineural invasion, intraoperative sufentanil consumption, and length of stay. We performed a subgroup group analysis to evaluate the interaction between levels of MOR expression, amount of opioids use (high 2021-01-01T00:00:00Z20212025-04-18T19:08:57.917Z2022-02-10T18:07:06.504ZS-EPMC82499183422201210.3389/fonc.2021.686877