{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12(1)"],"submitter":["Liu B"],"pubmed_abstract":["CCCH zinc finger proteins resolve immune responses by degrading the mRNAs of inflammatory cytokines such as tumor necrosis factor (TNF) and interleukin (IL)-6. Here we report that one such family member, monocyte chemotactic protein-induced protein 3 (MCPIP3, also named ZC3H12C or Regnase-3), promotes skin inflammation by simultaneously enhancing TNF in macrophages and repressing IL-6 in plasmacytoid dendritic cells (pDCs). MCPIP3 is positively associated with psoriasis pathogenesis, and highly expressed by macrophages and pDCs. MCPIP3-deficient macrophages produce less TNF and IL-12p40. However, MCPIP3-deficient pDCs secrete significantly more IL-6. This enhanced intradermal IL-6 may alleviate imiquimod-induced skin inflammation. As a result, MCPIP3-deficient mice are protected from imiqu"],"journal":["Nature communications"],"pagination":["4105"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8253787"],"repository":["biostudies-literature"],"pubmed_title":["The RNase MCPIP3 promotes skin inflammation by orchestrating myeloid cytokine response."],"pmcid":["PMC8253787"],"pubmed_authors":["Huang J","Cai P","Ni H","Ashraf A","Wang L","Liu X","Ganguly D","Wen J","Anwaar S","Rahaman O","Liu B","Yang CY","Zhao J","Lou J"],"additional_accession":[]},"is_claimable":false,"name":"The RNase MCPIP3 promotes skin inflammation by orchestrating myeloid cytokine response.","description":"CCCH zinc finger proteins resolve immune responses by degrading the mRNAs of inflammatory cytokines such as tumor necrosis factor (TNF) and interleukin (IL)-6. Here we report that one such family member, monocyte chemotactic protein-induced protein 3 (MCPIP3, also named ZC3H12C or Regnase-3), promotes skin inflammation by simultaneously enhancing TNF in macrophages and repressing IL-6 in plasmacytoid dendritic cells (pDCs). MCPIP3 is positively associated with psoriasis pathogenesis, and highly expressed by macrophages and pDCs. MCPIP3-deficient macrophages produce less TNF and IL-12p40. However, MCPIP3-deficient pDCs secrete significantly more IL-6. This enhanced intradermal IL-6 may alleviate imiquimod-induced skin inflammation. As a result, MCPIP3-deficient mice are protected from imiqu","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Jul","modification":"2026-05-07T19:54:39.521Z","creation":"2022-02-10T21:40:34.956Z"},"accession":"S-EPMC8253787","cross_references":{"pubmed":["34215755"],"doi":["10.1038/s41467-021-24352-w"]}}