{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Presley CJ"],"funding":["NCATS NIH HHS","NIA NIH HHS","NCI NIH HHS"],"pagination":["e848-e858"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8258136"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["17(6)"],"pubmed_abstract":["<h4>Purpose</h4>To determine patient and disease characteristics associated with functional disability among adults with advanced non-small-cell lung cancer (NSCLC).<h4>Methods</h4>In a prospective cohort of participants newly diagnosed with advanced NSCLC and beginning systemic treatment, functional disability in usual activities, mobility, and self-care was measured using the EuroQol-5D-5L at baseline. Demographics, comorbidities, brain metastases, Eastern Cooperative Oncology Group performance status (ECOG PS), and psychologic variables (depression [Patient Health Questionnaire-9] and anxiety [Generalized Anxiety Disorder 7-item scale]) were captured. Patients were classified into two disability groups (none-slight or moderate-severe) on the basis of total functional status scores. Differences between disability groups were determined (chi-square and <i>t</i> tests). Associations between patient characteristics and baseline disability were assessed using logistic regression.<h4>Results</h4>Among 173 participants, mean age was 63.3 years, 56% were male, 83% had ECOG PS 0-1, and 41% had brain metastases. Baseline disability was present in 39% of participants, with patients having moderate to severe disability in usual activities (37.6%), mobility (26.6%), and self-care (5.2%). Depressive and/or anxiety symptoms ranged from none to severe (Patient Health Questionnaire 9-item scale M = 6.5, SD = 5.3). Depressive symptoms were the only characteristic associated with a higher odds of baseline disability (adjusted odds ratio [aOR]: 1.26; 95% CI, 1.15 to 1.38; <i>P</i> < .001). Participants with poorer ECOG PS (aOR: 4.64; 95% CI, 1.84 to 11.68; <i>P</i> = .001) and depressive symptoms (aOR: 1.15; 95% CI, 1.07 to 1.24; <i>P</i> < .001) had higher odds of moderate-severe mobility disability compared with the none-slight disability group.<h4>Conclusion</h4>More than one third of all adults with advanced NSCLC have moderate-severe functional disability at baseline. Psychologic symptoms were significantly associated with moderate-severe baseline disability."],"journal":["JCO oncology practice"],"pubmed_title":["Functional Disability Among Older Versus Younger Adults With Advanced Non-Small-Cell Lung Cancer."],"pmcid":["PMC8258136"],"funding_grant_id":["K12 CA133250","P30 AG021342","K76 AG064431","R03 AG064374","UL1 TR001863","P30 AG044281"],"pubmed_authors":["Arrato NA","Allore HG","Carbone DP","Shields PG","Presley CJ","Han L","Andersen BL","Janse S","Wong ML","Gill TM"],"additional_accession":[]},"is_claimable":false,"name":"Functional Disability Among Older Versus Younger Adults With Advanced Non-Small-Cell Lung Cancer.","description":"<h4>Purpose</h4>To determine patient and disease characteristics associated with functional disability among adults with advanced non-small-cell lung cancer (NSCLC).<h4>Methods</h4>In a prospective cohort of participants newly diagnosed with advanced NSCLC and beginning systemic treatment, functional disability in usual activities, mobility, and self-care was measured using the EuroQol-5D-5L at baseline. Demographics, comorbidities, brain metastases, Eastern Cooperative Oncology Group performance status (ECOG PS), and psychologic variables (depression [Patient Health Questionnaire-9] and anxiety [Generalized Anxiety Disorder 7-item scale]) were captured. Patients were classified into two disability groups (none-slight or moderate-severe) on the basis of total functional status scores. Differences between disability groups were determined (chi-square and <i>t</i> tests). Associations between patient characteristics and baseline disability were assessed using logistic regression.<h4>Results</h4>Among 173 participants, mean age was 63.3 years, 56% were male, 83% had ECOG PS 0-1, and 41% had brain metastases. Baseline disability was present in 39% of participants, with patients having moderate to severe disability in usual activities (37.6%), mobility (26.6%), and self-care (5.2%). Depressive and/or anxiety symptoms ranged from none to severe (Patient Health Questionnaire 9-item scale M = 6.5, SD = 5.3). Depressive symptoms were the only characteristic associated with a higher odds of baseline disability (adjusted odds ratio [aOR]: 1.26; 95% CI, 1.15 to 1.38; <i>P</i> < .001). Participants with poorer ECOG PS (aOR: 4.64; 95% CI, 1.84 to 11.68; <i>P</i> = .001) and depressive symptoms (aOR: 1.15; 95% CI, 1.07 to 1.24; <i>P</i> < .001) had higher odds of moderate-severe mobility disability compared with the none-slight disability group.<h4>Conclusion</h4>More than one third of all adults with advanced NSCLC have moderate-severe functional disability at baseline. Psychologic symptoms were significantly associated with moderate-severe baseline disability.","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Jun","modification":"2025-04-04T19:32:08.361Z","creation":"2025-02-19T02:58:33.096Z"},"accession":"S-EPMC8258136","cross_references":{"pubmed":["33939536"],"doi":["10.1200/OP.20.01004","10.1200/op.20.01004"]}}