biostudies-literaturePresley CJNCATS NIH HHSNIA NIH HHSNCI NIH HHSe848-e858https://www.ebi.ac.uk/biostudies/studies/S-EPMC8258136biostudies-literatureUnknown17(6)<h4>Purpose</h4>To determine patient and disease characteristics associated with functional disability among adults with advanced non-small-cell lung cancer (NSCLC).<h4>Methods</h4>In a prospective cohort of participants newly diagnosed with advanced NSCLC and beginning systemic treatment, functional disability in usual activities, mobility, and self-care was measured using the EuroQol-5D-5L at baseline. Demographics, comorbidities, brain metastases, Eastern Cooperative Oncology Group performance status (ECOG PS), and psychologic variables (depression [Patient Health Questionnaire-9] and anxiety [Generalized Anxiety Disorder 7-item scale]) were captured. Patients were classified into two disability groups (none-slight or moderate-severe) on the basis of total functional status scores. Differences between disability groups were determined (chi-square and <i>t</i> tests). Associations between patient characteristics and baseline disability were assessed using logistic regression.<h4>Results</h4>Among 173 participants, mean age was 63.3 years, 56% were male, 83% had ECOG PS 0-1, and 41% had brain metastases. Baseline disability was present in 39% of participants, with patients having moderate to severe disability in usual activities (37.6%), mobility (26.6%), and self-care (5.2%). Depressive and/or anxiety symptoms ranged from none to severe (Patient Health Questionnaire 9-item scale M = 6.5, SD = 5.3). Depressive symptoms were the only characteristic associated with a higher odds of baseline disability (adjusted odds ratio [aOR]: 1.26; 95% CI, 1.15 to 1.38; <i>P</i> < .001). Participants with poorer ECOG PS (aOR: 4.64; 95% CI, 1.84 to 11.68; <i>P</i> = .001) and depressive symptoms (aOR: 1.15; 95% CI, 1.07 to 1.24; <i>P</i> < .001) had higher odds of moderate-severe mobility disability compared with the none-slight disability group.<h4>Conclusion</h4>More than one third of all adults with advanced NSCLC have moderate-severe functional disability at baseline. Psychologic symptoms were significantly associated with moderate-severe baseline disability.JCO oncology practiceFunctional Disability Among Older Versus Younger Adults With Advanced Non-Small-Cell Lung Cancer.PMC8258136K12 CA133250P30 AG021342K76 AG064431R03 AG064374UL1 TR001863P30 AG044281Arrato NAAllore HGCarbone DPShields PGPresley CJHan LAndersen BLJanse SWong MLGill TMfalseFunctional Disability Among Older Versus Younger Adults With Advanced Non-Small-Cell Lung Cancer.<h4>Purpose</h4>To determine patient and disease characteristics associated with functional disability among adults with advanced non-small-cell lung cancer (NSCLC).<h4>Methods</h4>In a prospective cohort of participants newly diagnosed with advanced NSCLC and beginning systemic treatment, functional disability in usual activities, mobility, and self-care was measured using the EuroQol-5D-5L at baseline. Demographics, comorbidities, brain metastases, Eastern Cooperative Oncology Group performance status (ECOG PS), and psychologic variables (depression [Patient Health Questionnaire-9] and anxiety [Generalized Anxiety Disorder 7-item scale]) were captured. Patients were classified into two disability groups (none-slight or moderate-severe) on the basis of total functional status scores. Differences between disability groups were determined (chi-square and <i>t</i> tests). Associations between patient characteristics and baseline disability were assessed using logistic regression.<h4>Results</h4>Among 173 participants, mean age was 63.3 years, 56% were male, 83% had ECOG PS 0-1, and 41% had brain metastases. Baseline disability was present in 39% of participants, with patients having moderate to severe disability in usual activities (37.6%), mobility (26.6%), and self-care (5.2%). Depressive and/or anxiety symptoms ranged from none to severe (Patient Health Questionnaire 9-item scale M = 6.5, SD = 5.3). Depressive symptoms were the only characteristic associated with a higher odds of baseline disability (adjusted odds ratio [aOR]: 1.26; 95% CI, 1.15 to 1.38; <i>P</i> < .001). Participants with poorer ECOG PS (aOR: 4.64; 95% CI, 1.84 to 11.68; <i>P</i> = .001) and depressive symptoms (aOR: 1.15; 95% CI, 1.07 to 1.24; <i>P</i> < .001) had higher odds of moderate-severe mobility disability compared with the none-slight disability group.<h4>Conclusion</h4>More than one third of all adults with advanced NSCLC have moderate-severe functional disability at baseline. Psychologic symptoms were significantly associated with moderate-severe baseline disability.2021-01-01T00:00:00Z2021 Jun2025-04-04T19:32:08.361Z2025-02-19T02:58:33.096ZS-EPMC82581363393953610.1200/OP.20.0100410.1200/op.20.01004