biostudies-literatureRamspek CLNierstichtingNational Institute for Health Research (NIHR)1174-1186https://www.ebi.ac.uk/biostudies/studies/S-EPMC8259669biostudies-literatureUnknown32(5)<h4>Background</h4>Various prediction models have been developed to predict the risk of kidney failure in patients with CKD. However, guideline-recommended models have yet to be compared head to head, their validation in patients with advanced CKD is lacking, and most do not account for competing risks.<h4>Methods</h4>To externally validate 11 existing models of kidney failure, taking the competing risk of death into account, we included patients with advanced CKD from two large cohorts: the European Quality Study (EQUAL), an ongoing European prospective, multicenter cohort study of older patients with advanced CKD, and the Swedish Renal Registry (SRR), an ongoing registry of nephrology-referred patients with CKD in Sweden. The outcome of the models was kidney failure (defined as RRT-treatJournal of the American Society of Nephrology : JASNKidney Failure Prediction Models: A Comprehensive External Validation Study in Patients with Advanced CKD.PMC825966916OKG12ACF-2018-25-006Russo DTognarelli GChesnaye NCPozzi CMotta DMcNally HCiurlino DGaillard CNeumeier KMcKeever AGlowski DStephan TWanner CBaragetti IMalaguti MRoderick PJager KJKooman JMagnano MSchulz PRanghino ANavjee SCappellaio FCicchetti TLeimbach TFerraro ANigro RMcGlynn DHahn KMele ABahner UUllah ANowanska KNaujoks HGambaro GRothele JDurlik MBoero RRenker STorp AStucchi ARoy GTurner JPerras BStendahl MLuisa Sirico MManan SWong JDe Simone WGarofalo CO'Toole CSchrander AAcampora PMangano SZullo CMarx CIchtiaris PRogland BTsalouichos ACosaro ACockwell PKalra PBlom ALMusiala AMazur JBoom HRaasveld MRamspek CLEijgenraam JWTorino CFrischmuth ND'alessandro Cvan Diepen MBlaser CKashioulis PEvans MOlczyk EBascaran Hernandez IMaffei SDekker FWVervloet MBoots HMurtagh HSchlee ISchlee HBorrelli SPani AMiskowiec-Wisniewska IWeinreich TWilkinson LSundelin FKrieter DSavoldi SSagliocca ANieszporek TAntonio BStovesand TJones KDi Iorio BREmde CToscano GWoodman ARappa TBanda JSummersgill CMasri-Senghor HBeerenhout CGeddes CRotmans JVerburgh CFerraresi MKrajewska MBertoli SSiegert CBlouin KSands DWilcox JJensen UAnsali FGesualdo LDrechsler CCaloro GSchmidt-Gurtler HScarpioni RGrontoft KCProvenzano MSvensson MBergamo DDe Blasio Avan Dam BWeetman MAugustyniak-Bartosik HCrosbie SPalm SCasar SEQUAL Study InvestigatorsHoogeveen EBiancone LMaxia SBonforte GDi Bari MJoinson MDelrieux SMatthews MHeidenreich SKuan YBiribauer SGiacchino FDutton MRayner HHayward SBigatti GPondel JAbaterusso CSeeger WDattolo PSchmiedeke Tvan Buren MVogt LWuttke NMason PIwig BAign SBeige JRicardi MVigotti FMarinangeli GManitius JPalmieri NPorto GCaskey FHaydock LSajith RHarron CPizzarelli FHirst GBleakley Nvan Esch SAlessandra BPalazzo VVargas DConte GSchneider AConte FKirste PCupisti AFavaro ECirillo PHopf MLaudato MCapizzi IMalandra RGreco GPignataro AAlmquist TBlankestijn PDel Rosso GLeurs POldrizzi LNaticchia AWelander GMelander SSicoli RJedrzejak KBoorsma SAydin ZCabiddu GVoskamp PJonsson AUhlin FKonings SDimeny EAnding-Rost KSchramm LPiccoli GBarrett CSchattel SNowak LFumagalli GPlaten EMathavakkannan SSchwedler SMurrone PHeleniak ZCarmody MCianciotta FSzymczak MCapasso GIrmler EKing HSomma CSzymczak AMcLaren BWallquist CBerdeprado JHoorn EChapman SDorota SRoser SFuchs DMorgan NBrown STickle SfalseKidney Failure Prediction Models: A Comprehensive External Validation Study in Patients with Advanced CKD.<h4>Background</h4>Various prediction models have been developed to predict the risk of kidney failure in patients with CKD. However, guideline-recommended models have yet to be compared head to head, their validation in patients with advanced CKD is lacking, and most do not account for competing risks.<h4>Methods</h4>To externally validate 11 existing models of kidney failure, taking the competing risk of death into account, we included patients with advanced CKD from two large cohorts: the European Quality Study (EQUAL), an ongoing European prospective, multicenter cohort study of older patients with advanced CKD, and the Swedish Renal Registry (SRR), an ongoing registry of nephrology-referred patients with CKD in Sweden. The outcome of the models was kidney failure (defined as RRT-treat2021-01-01T00:00:00Z2021 May2025-04-05T10:03:42.403Z2025-04-05T10:03:42.403ZS-EPMC82596693368597410.1681/asn.202007107710.1681/ASN.2020071077