{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Hanson P"],"funding":["Medical Research Council"],"pagination":["145470"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8262470"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["6(12)"],"pubmed_abstract":["<h4>Background</h4>Dietary sodium intake mismatches urinary sodium excretion over prolonged periods. Our aims were to localize and quantify electrostatically bound sodium within human skin using triple-quantum-filtered (TQF) protocols for MRI and magnetic resonance spectroscopy (MRS) and to explore dermal sodium in type 2 diabetes mellitus (T2D).<h4>Methods</h4>We recruited adult participants with T2D (n = 9) and euglycemic participants with no history of diabetes mellitus (n = 8). All had undergone lower limb amputations or abdominal skin reduction surgery for clinical purposes. We used 20 μm in-plane resolution 1H MRI to visualize anatomical skin regions ex vivo from skin biopsies taken intraoperatively, 23Na TQF MRI/MRS to explore distribution and quantification of freely dissolved and "],"journal":["JCI insight"],"pubmed_title":["Sodium in the dermis colocates to glycosaminoglycan scaffold, with diminishment in type 2 diabetes mellitus."],"pmcid":["PMC8262470"],"funding_grant_id":["MC_PC_15074"],"pubmed_authors":["Hanson P","James S","O'Hare JP","Meersmann T","Barber TM","Pavlovskaya GE","Randeva HS","Philp CJ"],"additional_accession":[]},"is_claimable":false,"name":"Sodium in the dermis colocates to glycosaminoglycan scaffold, with diminishment in type 2 diabetes mellitus.","description":"<h4>Background</h4>Dietary sodium intake mismatches urinary sodium excretion over prolonged periods. Our aims were to localize and quantify electrostatically bound sodium within human skin using triple-quantum-filtered (TQF) protocols for MRI and magnetic resonance spectroscopy (MRS) and to explore dermal sodium in type 2 diabetes mellitus (T2D).<h4>Methods</h4>We recruited adult participants with T2D (n = 9) and euglycemic participants with no history of diabetes mellitus (n = 8). All had undergone lower limb amputations or abdominal skin reduction surgery for clinical purposes. We used 20 μm in-plane resolution 1H MRI to visualize anatomical skin regions ex vivo from skin biopsies taken intraoperatively, 23Na TQF MRI/MRS to explore distribution and quantification of freely dissolved and ","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Jun","modification":"2026-07-16T11:10:17.484Z","creation":"2022-02-10T19:33:21.559Z"},"accession":"S-EPMC8262470","cross_references":{"pubmed":["34003801"],"doi":["10.1172/jci.insight.145470"]}}