biostudies-literatureUnknown10(6)Dempke WCMRecently approved and highly specific small-molecule inhibitors of c-MET exon 14 skipping mutations (e.g., capmatinib, tepotinib) are a new and important therapeutic option for the treatment of non-small cell lung cancer (NSCLC) patients harbouring c-MET alterations. Several experimental studies have provided compelling evidence that c-MET is involved in the regulation of the immune response by up-regulating inhibitory molecules (e.g., PD-L1) and down-regulating of immune stimulators (e.g., CD137, CD252, CD70, etc.). In addition, c-MET was found to be implicated in the regulation of the inflamed tumour microenvironment (TME) and thereby contributing to an increased immune escape of tumour cells from T cell killing. Moreover, it is a major resistance mechanism following treatment of epidermTranslational lung cancer research2667-2682https://www.ebi.ac.uk/biostudies/studies/S-EPMC8264346biostudies-literatureHas programmed cell death ligand-1 <i>MET</i> an accomplice in non-small cell lung cancer?-a narrative review.PMC8264346Fenchel KDempke WCMfalseHas programmed cell death ligand-1 <i>MET</i> an accomplice in non-small cell lung cancer?-a narrative review.Recently approved and highly specific small-molecule inhibitors of c-MET exon 14 skipping mutations (e.g., capmatinib, tepotinib) are a new and important therapeutic option for the treatment of non-small cell lung cancer (NSCLC) patients harbouring c-MET alterations. Several experimental studies have provided compelling evidence that c-MET is involved in the regulation of the immune response by up-regulating inhibitory molecules (e.g., PD-L1) and down-regulating of immune stimulators (e.g., CD137, CD252, CD70, etc.). In addition, c-MET was found to be implicated in the regulation of the inflamed tumour microenvironment (TME) and thereby contributing to an increased immune escape of tumour cells from T cell killing. Moreover, it is a major resistance mechanism following treatment of epiderm2021-01-01T00:00:00Z2021 Jun2025-04-04T09:37:43.005Z2025-04-04T09:37:43.005ZS-EPMC82643463429566910.21037/tlcr-21-124