{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Sun S"],"funding":["Social Development and Scientific-technological Foundation of Zhenjiang"],"pagination":["1209-1219"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8265791"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["20(12)"],"pubmed_abstract":["Ankylosing spondylitis (AS) is a chronic autoimmune disease in which let-7i has been studied to involved. But, whether let-7i-3p could regulate osteoblast differentiation in AS remains unclear. This research targeted to decipher the impact of let-7i-3p on AS progression by modulating pyruvate dehydrogenase kinase 1 (PDK1). The bone mineral density of femur and lumbar vertebra and the maximum loading and bending elastic modulus of tibia, tumor necrosis factor-α (TNF-α), matrix metalloproteinase (MMP)-3, osteoprotegerin (OPG) and receptor activator of nuclear factor-κB ligand (RANKL) in serum of AS mice, the pathological condition of synovial tissue were determined via let-7i-3p inhibitor and OE-PDK1 in animal experiment. Also, the cell viability and ALP activity were measured by let-7i-3p i"],"journal":["Cell cycle (Georgetown, Tex.)"],"pubmed_title":["MicroRNA let-7i-3p affects osteoblast differentiation in ankylosing spondylitis via targeting PDK1."],"pmcid":["PMC8265791"],"funding_grant_id":["SH2018040"],"pubmed_authors":["Liu H","Zhu Z","Sun S","Kong D","Xu Y","Zhou Z","Wang L"],"additional_accession":[]},"is_claimable":false,"name":"MicroRNA let-7i-3p affects osteoblast differentiation in ankylosing spondylitis via targeting PDK1.","description":"Ankylosing spondylitis (AS) is a chronic autoimmune disease in which let-7i has been studied to involved. But, whether let-7i-3p could regulate osteoblast differentiation in AS remains unclear. This research targeted to decipher the impact of let-7i-3p on AS progression by modulating pyruvate dehydrogenase kinase 1 (PDK1). The bone mineral density of femur and lumbar vertebra and the maximum loading and bending elastic modulus of tibia, tumor necrosis factor-α (TNF-α), matrix metalloproteinase (MMP)-3, osteoprotegerin (OPG) and receptor activator of nuclear factor-κB ligand (RANKL) in serum of AS mice, the pathological condition of synovial tissue were determined via let-7i-3p inhibitor and OE-PDK1 in animal experiment. Also, the cell viability and ALP activity were measured by let-7i-3p i","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Jun","modification":"2025-04-19T20:44:43.041Z","creation":"2025-04-19T20:44:43.041Z"},"accession":"S-EPMC8265791","cross_references":{"pubmed":["34048311"],"doi":["10.1080/15384101.2021.1930680"]}}