{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Domzalska M"],"funding":["KNOW (Leading National Research Centre) Scientific Consortium “Healthy Animal – Safe Food”"],"pagination":["7122"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8268849"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["22(13)"],"pubmed_abstract":["Quercetin-3-glucuronide (Q3GA), the main phase II metabolite of quercetin (Q) in human plasma, is considered to be a more stable form of Q for transport with the bloodstream to tissues, where it can be potentially deconjugated by β-glucuronidase (β-Gluc) to Q aglycone, which easily enters the brain. This study evaluates the effect of lipopolysaccharide (LPS)-induced acute inflammation on β-Gluc gene expression in the choroid plexus (ChP) and its activity in blood plasma, ChP and cerebrospinal fluid (CSF), and the concentration of Q and its phase II metabolites in blood plasma and CSF. Studies were performed on saline- and LPS-treated adult ewes (n = 40) receiving Q3GA intravenously (n = 16) and on primary rat ChP epithelial cells and human ChP epithelial papilloma cells. We observed that a"],"journal":["International journal of molecular sciences"],"pubmed_title":["Effect of Lipopolysaccharide-Induced Inflammatory Challenge on β-Glucuronidase Activity and the Concentration of Quercetin and Its Metabolites in the Choroid Plexus, Blood Plasma and Cerebrospinal Fluid."],"pmcid":["PMC8268849"],"funding_grant_id":["05-1/KNOW2/2015"],"pubmed_authors":["Schroten H","Schwerk C","Deli MA","Wiczkowski W","Chojnowska S","Walter FR","Domzalska M","Skipor J","Szczepkowska A","Misztal T","Ishikawa H"],"additional_accession":[]},"is_claimable":false,"name":"Effect of Lipopolysaccharide-Induced Inflammatory Challenge on β-Glucuronidase Activity and the Concentration of Quercetin and Its Metabolites in the Choroid Plexus, Blood Plasma and Cerebrospinal Fluid.","description":"Quercetin-3-glucuronide (Q3GA), the main phase II metabolite of quercetin (Q) in human plasma, is considered to be a more stable form of Q for transport with the bloodstream to tissues, where it can be potentially deconjugated by β-glucuronidase (β-Gluc) to Q aglycone, which easily enters the brain. This study evaluates the effect of lipopolysaccharide (LPS)-induced acute inflammation on β-Gluc gene expression in the choroid plexus (ChP) and its activity in blood plasma, ChP and cerebrospinal fluid (CSF), and the concentration of Q and its phase II metabolites in blood plasma and CSF. Studies were performed on saline- and LPS-treated adult ewes (n = 40) receiving Q3GA intravenously (n = 16) and on primary rat ChP epithelial cells and human ChP epithelial papilloma cells. We observed that a","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Jul","modification":"2025-04-26T05:08:54.234Z","creation":"2022-02-10T21:47:46.601Z"},"accession":"S-EPMC8268849","cross_references":{"pubmed":["34281178"],"doi":["10.3390/ijms22137122"]}}