biostudies-literatureUnknown8Charmet T<h4>Background</h4>We aimed to assess the effectiveness of two doses of mRNA COVID-19 vaccines against COVID-19 with the original virus and other lineages circulating in France.<h4>Methods</h4>In this nationwide case-control study, cases were SARS-CoV-2 infected adults with onset of symptoms between 14 February and 3 May 2021. Controls were non-infected adults from a national representative panel matched to cases by age, sex, region, population density and calendar week. Participants completed an online questionnaire on recent activity-related exposures and vaccination history. Information about the infecting virus was based on a screening RT-PCR for either B.1.1.7 or B.1.351/P.1 variants.<h4>Findings</h4>Included in our analysis were 7 288 adults infected with the original SARS-CoV-2 viruThe Lancet regional health. Europe100171https://www.ebi.ac.uk/biostudies/studies/S-EPMC8277121biostudies-literatureImpact of original, B.1.1.7, and B.1.351/P.1 SARS-CoV-2 lineages on vaccine effectiveness of two doses of COVID-19 mRNA vaccines: Results from a nationwide case-control study in France.PMC8277121Septfons Avan der Werf SGrant RMaurizot ARogoff AGalmiche SCheny OMailles ASchaeffer LOmar FDavid CVon Platen CCharmet TGaymard ACarrat FFontanet ACauchemez SEnouf VLevy-Bruhl DLina BLefrancois LHfalseImpact of original, B.1.1.7, and B.1.351/P.1 SARS-CoV-2 lineages on vaccine effectiveness of two doses of COVID-19 mRNA vaccines: Results from a nationwide case-control study in France.<h4>Background</h4>We aimed to assess the effectiveness of two doses of mRNA COVID-19 vaccines against COVID-19 with the original virus and other lineages circulating in France.<h4>Methods</h4>In this nationwide case-control study, cases were SARS-CoV-2 infected adults with onset of symptoms between 14 February and 3 May 2021. Controls were non-infected adults from a national representative panel matched to cases by age, sex, region, population density and calendar week. Participants completed an online questionnaire on recent activity-related exposures and vaccination history. Information about the infecting virus was based on a screening RT-PCR for either B.1.1.7 or B.1.351/P.1 variants.<h4>Findings</h4>Included in our analysis were 7 288 adults infected with the original SARS-CoV-2 viru2021-01-01T00:00:00Z2021 Sep2026-05-07T22:59:00.372Z2022-02-11T15:36:40.637ZS-EPMC82771213427837210.1016/j.lanepe.2021.100171