{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Saito H"],"funding":["Sumitomo Foundation","Core Research for Evolutional Science and Technology","Japan Society for the Promotion of Science"],"pagination":["9546-9555"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8278973"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(27)"],"pubmed_abstract":["Organic synthesis is performed based on precise choices of functional groups and reactions employed. In a multistep synthesis, an ideal functional group should be compatible with various reaction conditions and unaltered until it is subjected to a selective conversion. The current study was set out to search for a silicon functionality that meets these criteria. Here we have established a new silicon-based synthetic methodology centred on a bulky 7-membered dialkoxysilyl group (2,4,4,7,7-pentamethyl-1,3,2-dioxasilepan-2-yl) that uniquely has both stability and on-demand reactivity. The exceptional stability of this functional group was corroborated by both experimental and computational studies which demonstrated that key factors for its stability were a 7-membered structure and steric hin"],"journal":["Chemical science"],"pubmed_title":["The dioxasilepanyl group as a versatile organometallic unit: studies on stability, reactivity, and utility."],"pmcid":["PMC8278973"],"funding_grant_id":["JP18J22838","JS21H01934","JPMJCR19R4","JP19H00895"],"pubmed_authors":["Shimokawa J","Saito H","Yorimitsu H"],"additional_accession":[]},"is_claimable":false,"name":"The dioxasilepanyl group as a versatile organometallic unit: studies on stability, reactivity, and utility.","description":"Organic synthesis is performed based on precise choices of functional groups and reactions employed. In a multistep synthesis, an ideal functional group should be compatible with various reaction conditions and unaltered until it is subjected to a selective conversion. The current study was set out to search for a silicon functionality that meets these criteria. Here we have established a new silicon-based synthetic methodology centred on a bulky 7-membered dialkoxysilyl group (2,4,4,7,7-pentamethyl-1,3,2-dioxasilepan-2-yl) that uniquely has both stability and on-demand reactivity. The exceptional stability of this functional group was corroborated by both experimental and computational studies which demonstrated that key factors for its stability were a 7-membered structure and steric hin","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Jul","modification":"2026-05-08T03:39:23.777Z","creation":"2022-02-11T02:57:38.92Z"},"accession":"S-EPMC8278973","cross_references":{"pubmed":["34349929"],"doi":["10.1039/d1sc02083h"]}}