{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Muecksch F"],"funding":["NIAID NIH HHS"],"pubmed_abstract":["<h4>Background</h4>Serological assays are being deployed to monitor antibody responses in SARS-CoV-2 convalescents and vaccine recipients. There is a need to determine whether such assays can predict immunity, as antibody levels wane and viral variants emerge.<h4>Methods</h4>We measured antibodies in a cohort of SARS-CoV-2 infected patients using several high-throughput serological tests and functional neutralization assays. The effects of time and spike protein sequence variation on the performance and predictive value of the various assays was assessed.<h4>Findings</h4>Neutralizing antibody titers decreased over the first few months post-infection but stabilized thereafter, at about 30% of the level observed shortly after infection. Serological assays commonly used to measure antibodies "],"journal":["medRxiv : the preprint server for health sciences"],"pagination":["2021.07.02.21259939"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8282113"],"repository":["biostudies-literature"],"pubmed_title":["Longitudinal variation in SARS-CoV-2 antibody levels and emergence of viral variants: implications for the ability of serological assays to predict immunity."],"pmcid":["PMC8282113"],"funding_grant_id":["R01 AI078788","R01 AI050111"],"pubmed_authors":["Malloy K","Zhang F","Bieniasz P","Hatziioannou T","Schmidt F","Jenks S","McCance K","Squires M","Mavin S","Templeton K","Muecksch F","Batchelor B","Richardson C","Burns A","Furrie E","Godber I","Jarvis L","MacGuire J","Wise H"],"additional_accession":[]},"is_claimable":false,"name":"Longitudinal variation in SARS-CoV-2 antibody levels and emergence of viral variants: implications for the ability of serological assays to predict immunity.","description":"<h4>Background</h4>Serological assays are being deployed to monitor antibody responses in SARS-CoV-2 convalescents and vaccine recipients. There is a need to determine whether such assays can predict immunity, as antibody levels wane and viral variants emerge.<h4>Methods</h4>We measured antibodies in a cohort of SARS-CoV-2 infected patients using several high-throughput serological tests and functional neutralization assays. The effects of time and spike protein sequence variation on the performance and predictive value of the various assays was assessed.<h4>Findings</h4>Neutralizing antibody titers decreased over the first few months post-infection but stabilized thereafter, at about 30% of the level observed shortly after infection. Serological assays commonly used to measure antibodies ","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Jul","modification":"2026-06-19T03:18:12.936Z","creation":"2022-02-11T16:05:15.757Z"},"accession":"S-EPMC8282113","cross_references":{"pubmed":["34268524"],"doi":["10.1101/2021.07.02.21259939"]}}