biostudies-literatureSchulz SMartin Luther University Halle-Wittenberg3002439https://www.ebi.ac.uk/biostudies/studies/S-EPMC8282382biostudies-literatureUnknown2021<h4>Background</h4>The biological link between severe periodontitis and cardiovascular disease is well established. Both complex inflammatory diseases are influenced by genetic background. Therefore, the impact of genetic variations of receptors of the innate immune system-(Toll-like receptors (TLRs)) TLR2, TLR4, cluster of differentiation 14 (CD14), and the transcription factor nuclear factor-<i>κΒ</i> (NF-<i>κ</i>B)-was investigated.<h4>Materials and methods</h4>In this study (ClinicalTrials.gov identifier: NCT01045070), 1002 cardiovascular (CV) patients were included. In a 3-year follow-up period, new vascular events were assessed. SNPs in CD14 (rs2569190), NF-<i>κΒ</i> (rs28362491), TLR2 (rs5743708), and TLR4 (rs4986790) were genotyped. The impact of these genetic variants on severe peMediators of inflammationPolymorphism of CD14 Gene Is Associated with Adverse Outcome among Patients Suffering from Cardiovascular Disease.PMC8282382F/34/08Schaller HGSchlitt ASchneider SZielske MSchulz SReichert SHofmann BfalsePolymorphism of CD14 Gene Is Associated with Adverse Outcome among Patients Suffering from Cardiovascular Disease.<h4>Background</h4>The biological link between severe periodontitis and cardiovascular disease is well established. Both complex inflammatory diseases are influenced by genetic background. Therefore, the impact of genetic variations of receptors of the innate immune system-(Toll-like receptors (TLRs)) TLR2, TLR4, cluster of differentiation 14 (CD14), and the transcription factor nuclear factor-<i>κΒ</i> (NF-<i>κ</i>B)-was investigated.<h4>Materials and methods</h4>In this study (ClinicalTrials.gov identifier: NCT01045070), 1002 cardiovascular (CV) patients were included. In a 3-year follow-up period, new vascular events were assessed. SNPs in CD14 (rs2569190), NF-<i>κΒ</i> (rs28362491), TLR2 (rs5743708), and TLR4 (rs4986790) were genotyped. The impact of these genetic variants on severe pe2021-01-01T00:00:00Z20212025-04-04T07:18:11.818Z2022-02-10T23:47:17.975ZS-EPMC82823823430545210.1155/2021/3002439