biostudies-literatureAlbert CBaskent ÜniversitesiNIDDK NIH HHSDr. Werner Jackstädt-StiftungFoundation for the National Institutes of HealthB. Braun-Stiftung826-841.e1https://www.ebi.ac.uk/biostudies/studies/S-EPMC8283708biostudies-literatureUnknown76(6)<h4>Rationale & objective</h4>The usefulness of measures of neutrophil gelatinase-associated lipocalin (NGAL) in urine or plasma obtained on clinical laboratory platforms for predicting acute kidney injury (AKI) and AKI requiring dialysis (AKI-D) has not been fully evaluated. We sought to quantitatively summarize published data to evaluate the value of urinary and plasma NGAL for kidney risk prediction.<h4>Study design</h4>Literature-based meta-analysis and individual-study-data meta-analysis of diagnostic studies following PRISMA-IPD guidelines.<h4>Setting & study populations</h4>Studies of adults investigating AKI, severe AKI, and AKI-D in the setting of cardiac surgery, intensive care, or emergency department care using either urinary or plasma NGAL measured on clinical laboratory platfAmerican journal of kidney diseases : the official journal of the National Kidney FoundationNeutrophil Gelatinase-Associated Lipocalin Measured on Clinical Laboratory Platforms for the Prediction of Acute Kidney Injury and the Associated Need for Dialysis Therapy: A Systematic Review and Meta-analysis.PMC8283708P50 DK096418Camou FZapf AKim HDi Somma Sde Geus HRHNanas SCruz DDevarajan PNickolas TLBraun-Dullaeus RCKavalci CChen ZSoto KLentini PPipili CEndre ZHHjortrup PBRover CKaraolanis GLipcsey MMartensson JRalib APickering JWRonco CChocron SRosa-Diez GJLiebetrau CHaase MHaase-Fielitz ABellomo RHeinz JMuller CDoi KGarcia-Alvarez MAlbert ABreidthardt TAlbert CHur MfalseNeutrophil Gelatinase-Associated Lipocalin Measured on Clinical Laboratory Platforms for the Prediction of Acute Kidney Injury and the Associated Need for Dialysis Therapy: A Systematic Review and Meta-analysis.<h4>Rationale & objective</h4>The usefulness of measures of neutrophil gelatinase-associated lipocalin (NGAL) in urine or plasma obtained on clinical laboratory platforms for predicting acute kidney injury (AKI) and AKI requiring dialysis (AKI-D) has not been fully evaluated. We sought to quantitatively summarize published data to evaluate the value of urinary and plasma NGAL for kidney risk prediction.<h4>Study design</h4>Literature-based meta-analysis and individual-study-data meta-analysis of diagnostic studies following PRISMA-IPD guidelines.<h4>Setting & study populations</h4>Studies of adults investigating AKI, severe AKI, and AKI-D in the setting of cardiac surgery, intensive care, or emergency department care using either urinary or plasma NGAL measured on clinical laboratory platf2020-01-01T00:00:00Z2020 Dec2025-05-29T21:28:21.466Z2022-02-10T20:13:06.101ZS-EPMC82837083267915110.1053/j.ajkd.2020.05.015