{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Simpson CA"],"funding":["NCATS NIH HHS","NICHD NIH HHS","NCRR NIH HHS"],"pagination":["333-342"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8284876"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["185(2)"],"pubmed_abstract":["<h4>Objective</h4>GC/DBP effects on response to vitamin D supplementation have not been well-studied. Thus we assessed free and total 25-OHD after vitamin D treatment across the six common GC haplotypes.<h4>Design</h4>This double-blind, randomized study compared two vitamin D3 doses in healthy, urban-dwelling 6-month to 10-year-old children at-risk for vitamin D deficiency. Randomization was stratified by GC haplotype.<h4>Methods</h4>Children were randomized to receive 2800 or 7000 International Units of vitamin D3 weekly. 25-OHD and 1,25(OH)2D were sampled at baseline and after 1-6 months of supplementation.<h4>Results and conclusions</h4>One hundred ninety-two of 225 enrolled subjects completed the study. After one month, total 25-OHD increased with both doses and were higher with 7000 I"],"journal":["European journal of endocrinology"],"pubmed_title":["25-OHD response to vitamin D supplementation in children: effect of dose but not GC haplotype."],"pmcid":["PMC8284876"],"funding_grant_id":["RC1 HD063562","UL1 RR024139","UL1 TR001863"],"pubmed_authors":["Vanderschueren D","Simpson CA","Bouillon R","Zhang JH","Pennestri TC","Fu L","Cole DEC","Carpenter TO"],"additional_accession":[]},"is_claimable":false,"name":"25-OHD response to vitamin D supplementation in children: effect of dose but not GC haplotype.","description":"<h4>Objective</h4>GC/DBP effects on response to vitamin D supplementation have not been well-studied. Thus we assessed free and total 25-OHD after vitamin D treatment across the six common GC haplotypes.<h4>Design</h4>This double-blind, randomized study compared two vitamin D3 doses in healthy, urban-dwelling 6-month to 10-year-old children at-risk for vitamin D deficiency. Randomization was stratified by GC haplotype.<h4>Methods</h4>Children were randomized to receive 2800 or 7000 International Units of vitamin D3 weekly. 25-OHD and 1,25(OH)2D were sampled at baseline and after 1-6 months of supplementation.<h4>Results and conclusions</h4>One hundred ninety-two of 225 enrolled subjects completed the study. After one month, total 25-OHD increased with both doses and were higher with 7000 I","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Jul","modification":"2026-05-01T03:12:26.634Z","creation":"2022-07-23T18:59:46.665Z"},"accession":"S-EPMC8284876","cross_references":{"pubmed":["34128826"],"doi":["10.1530/EJE-21-0349","10.1530/eje-21-0349"]}}