{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Alam N"],"funding":["Innovative Research Group Project of the National Natural Science Foundation of China","Canada Excellence Research Chairs, Government of Canada","China Scholarship Council","Postdoctoral Research Foundation of China"],"pagination":["8641-8651"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8286161"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["28(13)"],"pubmed_abstract":["Lateral flow assay (LFA) is an important point-of-care (POC) test platform due to the associated portability, on-site testing, and low cost for diagnosis of pathogen infections and disease biomarkers. However, compared to high-end analyzers in hospitals, LFA devices, in particular, paper- based LFA tests, fall short in accuracy. This study focuses on two ways to improve LFAs: (1) using cellulose fibers, rather than glass fibers for a sample pad, and (2) incorporating a one-step simple, facile, and low cost PVA dam into the LFA. Both strategies (cellulose fiber as a sample pad and water dissolvable PVA dam) contributed to delaying the controlled biomolecule's flow through the nitrocellulose membrane's capillary channels resulting in increased bio-recognition time, thus contributing to the e"],"journal":["Cellulose (London, England)"],"pubmed_title":["Improving the sensitivity of cellulose fiber-based lateral flow assay by incorporating a water-dissolvable polyvinyl alcohol dam."],"pmcid":["PMC8286161"],"funding_grant_id":["21808132","201908610073","CRC 950231308","2018M633525"],"pubmed_authors":["Ni Y","He Z","Tong L","Tang R","Ahsan L","Alam N"],"additional_accession":[]},"is_claimable":false,"name":"Improving the sensitivity of cellulose fiber-based lateral flow assay by incorporating a water-dissolvable polyvinyl alcohol dam.","description":"Lateral flow assay (LFA) is an important point-of-care (POC) test platform due to the associated portability, on-site testing, and low cost for diagnosis of pathogen infections and disease biomarkers. However, compared to high-end analyzers in hospitals, LFA devices, in particular, paper- based LFA tests, fall short in accuracy. This study focuses on two ways to improve LFAs: (1) using cellulose fibers, rather than glass fibers for a sample pad, and (2) incorporating a one-step simple, facile, and low cost PVA dam into the LFA. Both strategies (cellulose fiber as a sample pad and water dissolvable PVA dam) contributed to delaying the controlled biomolecule's flow through the nitrocellulose membrane's capillary channels resulting in increased bio-recognition time, thus contributing to the e","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021","modification":"2025-05-29T14:37:43.035Z","creation":"2022-02-10T23:02:35.453Z"},"accession":"S-EPMC8286161","cross_references":{"pubmed":["34305338"],"doi":["10.1007/s10570-021-04083-3"]}}