{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13(1)"],"submitter":["Racilan AM"],"funding":["Fundação de Amparo à Pesquisa do Estado de Minas Gerais","Conselho Nacional de Desenvolvimento Científico e Tecnológico","Coordenação de Aperfeiçoamento de Pessoal de Nível Superior"],"pubmed_abstract":["<h4>Objective</h4>Angiotensin-converting-enzyme 2 (ACE2), the cell surface receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is found in a variety of reproductive tissues. The present study evaluated whether uterine fibroids and normal myometrium express ACE2 and, if so, at which tissue compartments.<h4>Methods</h4>We included 13 premenopausal women (age range 33-50 years, median 40 years) with uterine fibroids undergoing elective hysterectomy or myomectomy. Samples of leiomyoma (<i>n</i> = 12) and normal myometrial tissue (<i>n</i> = 8) were analyzed by immunohistochemistry for protein localization or by real time PCR for mRNA detection.<h4>Results</h4>In normal myometrium, ACE2 immunoreactivity was localized in smooth muscle fibers, arteriolar walls, and endothel"],"journal":["Journal of endometriosis and pelvic pain disorders"],"pagination":["20-24"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8287083"],"repository":["biostudies-literature"],"pubmed_title":["Angiotensin-converting enzyme 2, the SARS-CoV-2 cellular receptor, is widely expressed in human myometrium and uterine leiomyoma."],"pmcid":["PMC8287083"],"pubmed_authors":["Casalechi M","Racilan AM","Spagnolo-Souza A","Simoes-E-Silva AC","Pascoal-Xavier MA","Assis WA","Reis FM","Del Puerto HL"],"additional_accession":[]},"is_claimable":false,"name":"Angiotensin-converting enzyme 2, the SARS-CoV-2 cellular receptor, is widely expressed in human myometrium and uterine leiomyoma.","description":"<h4>Objective</h4>Angiotensin-converting-enzyme 2 (ACE2), the cell surface receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is found in a variety of reproductive tissues. The present study evaluated whether uterine fibroids and normal myometrium express ACE2 and, if so, at which tissue compartments.<h4>Methods</h4>We included 13 premenopausal women (age range 33-50 years, median 40 years) with uterine fibroids undergoing elective hysterectomy or myomectomy. Samples of leiomyoma (<i>n</i> = 12) and normal myometrial tissue (<i>n</i> = 8) were analyzed by immunohistochemistry for protein localization or by real time PCR for mRNA detection.<h4>Results</h4>In normal myometrium, ACE2 immunoreactivity was localized in smooth muscle fibers, arteriolar walls, and endothel","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Mar","modification":"2025-04-04T13:22:01.382Z","creation":"2022-02-10T23:36:58.891Z"},"accession":"S-EPMC8287083","cross_references":{"pubmed":["34307238"],"doi":["10.1177/2284026520954068"]}}