biostudies-literatureUnknown13(1)Racilan AMFundação de Amparo à Pesquisa do Estado de Minas GeraisConselho Nacional de Desenvolvimento Científico e TecnológicoCoordenação de Aperfeiçoamento de Pessoal de Nível Superior<h4>Objective</h4>Angiotensin-converting-enzyme 2 (ACE2), the cell surface receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is found in a variety of reproductive tissues. The present study evaluated whether uterine fibroids and normal myometrium express ACE2 and, if so, at which tissue compartments.<h4>Methods</h4>We included 13 premenopausal women (age range 33-50 years, median 40 years) with uterine fibroids undergoing elective hysterectomy or myomectomy. Samples of leiomyoma (<i>n</i> = 12) and normal myometrial tissue (<i>n</i> = 8) were analyzed by immunohistochemistry for protein localization or by real time PCR for mRNA detection.<h4>Results</h4>In normal myometrium, ACE2 immunoreactivity was localized in smooth muscle fibers, arteriolar walls, and endothelJournal of endometriosis and pelvic pain disorders20-24https://www.ebi.ac.uk/biostudies/studies/S-EPMC8287083biostudies-literatureAngiotensin-converting enzyme 2, the SARS-CoV-2 cellular receptor, is widely expressed in human myometrium and uterine leiomyoma.PMC8287083Casalechi MRacilan AMSpagnolo-Souza ASimoes-E-Silva ACPascoal-Xavier MAAssis WAReis FMDel Puerto HLfalseAngiotensin-converting enzyme 2, the SARS-CoV-2 cellular receptor, is widely expressed in human myometrium and uterine leiomyoma.<h4>Objective</h4>Angiotensin-converting-enzyme 2 (ACE2), the cell surface receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is found in a variety of reproductive tissues. The present study evaluated whether uterine fibroids and normal myometrium express ACE2 and, if so, at which tissue compartments.<h4>Methods</h4>We included 13 premenopausal women (age range 33-50 years, median 40 years) with uterine fibroids undergoing elective hysterectomy or myomectomy. Samples of leiomyoma (<i>n</i> = 12) and normal myometrial tissue (<i>n</i> = 8) were analyzed by immunohistochemistry for protein localization or by real time PCR for mRNA detection.<h4>Results</h4>In normal myometrium, ACE2 immunoreactivity was localized in smooth muscle fibers, arteriolar walls, and endothel2021-01-01T00:00:00Z2021 Mar2025-04-04T13:22:01.382Z2022-02-10T23:36:58.891ZS-EPMC82870833430723810.1177/2284026520954068