{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Bilinska K"],"funding":["National Institutes of Health","NIGMS NIH HHS"],"pagination":["674123"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8287262"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15"],"pubmed_abstract":["Previous studies suggested that the SARS-CoV-2 virus may gain access to the brain by using a route along the olfactory nerve. However, there is a general consensus that the obligatory virus entry receptor, angiotensin converting enzyme 2 (ACE2), is not expressed in olfactory receptor neurons, and the timing of arrival of the virus in brain targets is inconsistent with a neuronal transfer along olfactory projections. We determined whether nervus terminalis neurons and their peripheral and central projections should be considered as a potential alternative route from the nose to the brain. Nervus terminalis neurons in postnatal mice were double-labeled with antibodies against ACE2 and two nervus terminalis markers, gonadotropin-releasing hormone (GnRH) and choline acetyltransferase (CHAT). W"],"journal":["Frontiers in cellular neuroscience"],"pubmed_title":["Expression of the ACE2 Virus Entry Protein in the Nervus Terminalis Reveals the Potential for an Alternative Route to Brain Infection in COVID-19."],"pmcid":["PMC8287262"],"funding_grant_id":["P20 GM103554"],"pubmed_authors":["Butowt R","Bilinska K","von Bartheld CS"],"additional_accession":[]},"is_claimable":false,"name":"Expression of the ACE2 Virus Entry Protein in the Nervus Terminalis Reveals the Potential for an Alternative Route to Brain Infection in COVID-19.","description":"Previous studies suggested that the SARS-CoV-2 virus may gain access to the brain by using a route along the olfactory nerve. However, there is a general consensus that the obligatory virus entry receptor, angiotensin converting enzyme 2 (ACE2), is not expressed in olfactory receptor neurons, and the timing of arrival of the virus in brain targets is inconsistent with a neuronal transfer along olfactory projections. We determined whether nervus terminalis neurons and their peripheral and central projections should be considered as a potential alternative route from the nose to the brain. Nervus terminalis neurons in postnatal mice were double-labeled with antibodies against ACE2 and two nervus terminalis markers, gonadotropin-releasing hormone (GnRH) and choline acetyltransferase (CHAT). W","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021","modification":"2025-04-04T21:11:43.977Z","creation":"2022-02-10T23:02:38.378Z"},"accession":"S-EPMC8287262","cross_references":{"pubmed":["34290590"],"doi":["10.3389/fncel.2021.674123"]}}