{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12"],"submitter":["Spenle C"],"funding":["Agence Nationale de la Recherche"],"pubmed_abstract":["Radiotherapy, the most frequent treatment of oral squamous cell carcinomas (OSCC) besides surgery is employed to kill tumor cells but, radiotherapy may also promote tumor relapse where the immune-suppressive tumor microenvironment (TME) could be instrumental. We established a novel syngeneic grafting model from a carcinogen-induced tongue tumor, OSCC13, to address the impact of radiotherapy on OSCC. This model revealed similarities with human OSCC, recapitulating carcinogen-induced mutations found in smoking associated human tongue tumors, abundant tumor infiltrating leukocytes (TIL) and, spontaneous tumor cell dissemination to the local lymph nodes. Cultured OSCC13 cells and OSCC13-derived tongue tumors were sensitive to irradiation. At the chosen dose of 2 Gy mimicking treatment of human"],"journal":["Frontiers in immunology"],"pagination":["636108"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8287883"],"repository":["biostudies-literature"],"pubmed_title":["Impact of Tenascin-C on Radiotherapy in a Novel Syngeneic Oral Squamous Cell Carcinoma Model With Spontaneous Dissemination to the Lymph Nodes."],"pmcid":["PMC8287883"],"pubmed_authors":["Loustau T","Burckel H","Ahowesso C","Riegel G","Li C","Petti L","Steinbach F","Paul N","Anjuere F","Orend G","Noel G","Salome N","Jost C","Carapito R","Spenle C","Abou Faycal C","Yilmaz A"],"additional_accession":[]},"is_claimable":false,"name":"Impact of Tenascin-C on Radiotherapy in a Novel Syngeneic Oral Squamous Cell Carcinoma Model With Spontaneous Dissemination to the Lymph Nodes.","description":"Radiotherapy, the most frequent treatment of oral squamous cell carcinomas (OSCC) besides surgery is employed to kill tumor cells but, radiotherapy may also promote tumor relapse where the immune-suppressive tumor microenvironment (TME) could be instrumental. We established a novel syngeneic grafting model from a carcinogen-induced tongue tumor, OSCC13, to address the impact of radiotherapy on OSCC. This model revealed similarities with human OSCC, recapitulating carcinogen-induced mutations found in smoking associated human tongue tumors, abundant tumor infiltrating leukocytes (TIL) and, spontaneous tumor cell dissemination to the local lymph nodes. Cultured OSCC13 cells and OSCC13-derived tongue tumors were sensitive to irradiation. At the chosen dose of 2 Gy mimicking treatment of human","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021","modification":"2026-05-07T22:56:14.775Z","creation":"2026-04-07T23:22:23.46Z"},"accession":"S-EPMC8287883","cross_references":{"pubmed":["34290694"],"doi":["10.3389/fimmu.2021.636108"]}}