{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Yi E"],"funding":["National Basic Research Program of China","National Natural Science Foundation of China"],"pagination":["e479"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8288003"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11(7)"],"pubmed_abstract":["Chronic obstructive pulmonary disease is a complex condition with multiple etiologies, including inflammation. We identified a novel long noncoding RNA (lncRNA), interleukin 6 antisense RNA 1 (IL6-AS1), which is upregulated in this disease and is associated with airway inflammation. We found that IL6-AS1 promotes the expression of inflammatory factors, especially interleukin (IL) 6. Mechanistically, cytoplasmic IL6-AS1 acts as an endogenous sponge by competitively binding to the microRNA miR-149-5p to stabilize IL-6 mRNA. Nuclear IL6-AS1 promotes IL-6 transcription by recruiting early B-cell factor 1 to the IL-6 promoter, which increases the methylation of the H3K4 histone and acetylation of the H3K27 histone. We propose a model of lncRNA expression in both the nucleus and cytoplasm that e"],"journal":["Clinical and translational medicine"],"pubmed_title":["Long noncoding RNA IL6-AS1 is highly expressed in chronic obstructive pulmonary disease and is associated with interleukin 6 by targeting miR-149-5p and early B-cell factor 1."],"pmcid":["PMC8288003"],"funding_grant_id":["81670040","2016YFC1304101","81970045"],"pubmed_authors":["Zhang J","Pu J","Lin Z","Zhou Y","Huang P","Liang C","Lin B","Zheng M","Zhang Y","Hong W","Li B","Hao B","Ran P","Yi E"],"additional_accession":[]},"is_claimable":false,"name":"Long noncoding RNA IL6-AS1 is highly expressed in chronic obstructive pulmonary disease and is associated with interleukin 6 by targeting miR-149-5p and early B-cell factor 1.","description":"Chronic obstructive pulmonary disease is a complex condition with multiple etiologies, including inflammation. We identified a novel long noncoding RNA (lncRNA), interleukin 6 antisense RNA 1 (IL6-AS1), which is upregulated in this disease and is associated with airway inflammation. We found that IL6-AS1 promotes the expression of inflammatory factors, especially interleukin (IL) 6. Mechanistically, cytoplasmic IL6-AS1 acts as an endogenous sponge by competitively binding to the microRNA miR-149-5p to stabilize IL-6 mRNA. Nuclear IL6-AS1 promotes IL-6 transcription by recruiting early B-cell factor 1 to the IL-6 promoter, which increases the methylation of the H3K4 histone and acetylation of the H3K27 histone. We propose a model of lncRNA expression in both the nucleus and cytoplasm that e","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Jul","modification":"2026-05-08T21:50:14.306Z","creation":"2022-02-11T01:27:36.307Z"},"accession":"S-EPMC8288003","cross_references":{"pubmed":["34323408"],"doi":["10.1002/ctm2.479"]}}