biostudies-literatureAll of Us Research Program InvestigatorsNCI NIH HHSNIH HHS668-676https://www.ebi.ac.uk/biostudies/studies/S-EPMC8291101biostudies-literatureUnknown381(7)Knowledge gained from observational cohort studies has dramatically advanced the prevention and treatment of diseases. Many of these cohorts, however, are small, lack diversity, or do not provide comprehensive phenotype data. The All of Us Research Program plans to enroll a diverse group of at least 1 million persons in the United States in order to accelerate biomedical research and improve health. The program aims to make the research results accessible to participants, and it is developing new approaches to generate, access, and make data broadly available to approved researchers. All of Us opened for enrollment in May 2018 and currently enrolls participants 18 years of age or older from a network of more than 340 recruitment sites. Elements of the program protocol include health questiThe New England journal of medicineThe "All of Us" Research Program.PMC8291101OT2 OD026555OT2 OD026554OT2 OD026557OT2 OD026556OT2 OD026548OT2 OD025315OT2 OD025337OT2 OD023205OT2 OD026549OT2 OD023206P30 CA013148OT2 OD026551OT2 OD025285OT2 OD026550OT2 OD025277OT2 OD026553OT2 OD023132OT2 OD025276OT2 OD026552U24 OD023121U24 OD023176U24 OD023163U2C OD023196Metcalf GFunk GTheodorou AWilliams KSurkan KGoodman MThibodeau SPerkins ALazzara KFalcon ACalhoun EBier LAschebrook-Kilfoy BReiman ELopez-Class MTaylor BTaylor AMosby HHall KJain PJenkins GTopol ETsao PZwick MEKathiresan SJain NMazor KJenkins AHambright SDevaney SMcClain JHalanych JLevy DYoung WChurby LDedier JScherdin JSchach JWilliams REdgman-Levitan SMaene CCotler AWhite GQuarshie AGreenland PMoreno FCao JPeissig PWhite SKaushal RRico EGAhsan HPhilippakis ASummers RLubensky MDaviglus MWolfe KSawyer SJarvik GPRamirez AXerras DAll of Us Research Program InvestigatorsLabrinidis MCicek MKho ANeben CShahzad FTalavera GSchilling JLugo-Butler EKarnes JBlizinsky KKlein DGreen RIlori TWellis DPost AROjo AMaycock TReis SEHarris GGMcNamara DMohs DRoberts SIgho-Pemu PFowler SJayaprakash MAbreu LWaring SCarrasquillo OWyatt LRutter JLRosales CKorf BCohn EBrilliant MHunt CRichardson-Heron DGreenberg BMcNeely MBorowsky AArgos MSmalligan RChesla DMurray MO'Connor GPeters MRosser TCLongenecker SBisceglio IDeshpande NNSutherland SNelson DNolido NPalumbo MRoss MEWagner JMoore-Vogel JIsasi RDrezner MRoxas-Murray MD'Addezio NBahati MWilkins CHZuchner SWallace FMoran RJMartinez EChaffins JDoheny KFouad MWilbanks JWhittle JErtl KZheng KMenon UShirts BHDoerr MScully PTopper SPeltz CNatarajan KShah RCOran DWeiss SBastakoty DMurphy SSokan AMunoz FBasford MJackson JFarrar-Edwards DBaca-Motes KSoares MBHarris PChannamsetty VMuzny DMFranco ZEmpey PMangravite LO'Donnell CJNickerson DAO'Donnell CMuthuraman KNEichler EEAnderson CCaulder MStrenn RStepniak EHigginbotham JSchlueter EHarris KQuer GSchleuter EWarfield CFrancisco MCastro MFonseca VMcCloud CClark CPericak-Vance MAWilkins CLattimore PWHearne TMeeker DHandattu SCimino JGejman PVLockwood CMButler NAlonso ADelgado CDishman EEpstein MMiele LMassart MBillimek JMcCauley JSansbury HMTachanardi UMeller RSedillo DJDavis CPKunst LMathias DObedin-Maliver JPeterson RFrazar CTanner SBaldwin BRice DSuver CSteinhubl SJohnson CCFillardo GHogan WKim KBohnhorst JButts PHogarth MAGrand JMBegale MRoth BYasko LKippen KKnight SKoney JPhan TZhou AKarlson EWMarroquin OTepp RSmith JDGarriock HLewis CETringale SZiogas AChang KHamideh DAcemgil APrice PHiatt RJohnson TMHandberg EWilson AVilla JWinkler JAdams WGibbs RAllen NSimon GDenny JCRamos EMayo KOjo TWang AAndrade RRehm HLBoerwinkle EKhatri PMcCaslin AGharavi AChessler SSanders ARSmoller JWGlazer DWatson KGarber LSoto MMapes BWinn RGabriel SRandal FTaran AMici AStamoulos CSingh SKim KEPark HWeida TDow EBattaglia TOzenberger BCoughlin ERelova ROlorundare EQuyyumi AAMcGovern PPritchard CCAhmedani BJenks NJohnston HRHo JOrr GCarroll RLunn MRChisholm RHochfelder RBoutin NSoohoo SAnton-Culver HGoldstein DBLunt COh JMikita SChinea CDenman TFreeland CBibbins-Domingo KMartin GSLeBlanc AOhno-Machado LBauman MSitapati AMKing PGebo KKing KMalin BCronin RCrook EVisweswaran STrousdale RKMcLaren DFlorence BLBurnside EShenkman EBrown JEl-Kareh REJoseph CHripcsak GLam HKoebnick EfalseThe "All of Us" Research Program.Knowledge gained from observational cohort studies has dramatically advanced the prevention and treatment of diseases. Many of these cohorts, however, are small, lack diversity, or do not provide comprehensive phenotype data. The All of Us Research Program plans to enroll a diverse group of at least 1 million persons in the United States in order to accelerate biomedical research and improve health. The program aims to make the research results accessible to participants, and it is developing new approaches to generate, access, and make data broadly available to approved researchers. All of Us opened for enrollment in May 2018 and currently enrolls participants 18 years of age or older from a network of more than 340 recruitment sites. Elements of the program protocol include health questi2019-01-01T00:00:00Z2019 Aug2025-04-26T05:13:45.425Z2022-02-10T20:55:10.432ZS-EPMC82911013141218210.1056/nejmsr180993710.1056/NEJMsr1809937