biostudies-literatureUnknown7(7)Jeyaraman MThe contagiosity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has startled mankind and has brought our lives to a standstill. The treatment focused mainly on repurposed immunomodulatory and antiviral agents along with the availability of a few vaccines for prophylaxis to vanquish COVID-19. This seemingly mandates a deeper understanding of the disease pathogenesis. This necessitates a plausible extrapolation of cell-based therapy to COVID-19 and is regarded equivalently significant. Recently, correlative pieces of clinical evidence reported a robust decline in lymphocyte count in severe COVID-19 patients that suggest dysregulated immune responses as a key element contributing to the pathophysiological alterations. The large granular lymphocytes also known as natural killeHeliyone07635https://www.ebi.ac.uk/biostudies/studies/S-EPMC8294777biostudies-literatureBracing NK cell based therapy to relegate pulmonary inflammation in COVID-19.PMC8294777Jain RChellappan DKChannaiah Anudeep TJeyaraman MDilip SJKesari KKDholpuria SDua KKumar DDureja HOjha SMuthu SJha NKGupta GJha SKSushmitha ESBapat AGulati ASingh SKfalseBracing NK cell based therapy to relegate pulmonary inflammation in COVID-19.The contagiosity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has startled mankind and has brought our lives to a standstill. The treatment focused mainly on repurposed immunomodulatory and antiviral agents along with the availability of a few vaccines for prophylaxis to vanquish COVID-19. This seemingly mandates a deeper understanding of the disease pathogenesis. This necessitates a plausible extrapolation of cell-based therapy to COVID-19 and is regarded equivalently significant. Recently, correlative pieces of clinical evidence reported a robust decline in lymphocyte count in severe COVID-19 patients that suggest dysregulated immune responses as a key element contributing to the pathophysiological alterations. The large granular lymphocytes also known as natural kille2021-01-01T00:00:00Z2021 Jul2025-04-05T00:48:51.012Z2022-02-11T11:15:17.69ZS-EPMC82947773431259810.1016/j.heliyon.2021.e07635