{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Fortis S"],"funding":["NCATS NIH HHS","COPD Foundation","NIBIB NIH HHS","NIEHS NIH HHS","NHLBI NIH HHS","National Institutes of Health","CSRD VA"],"pagination":["94-103"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8295909"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["160(1)"],"pubmed_abstract":["<h4>Background</h4>Mild expiratory flow limitation may not be recognized using traditional spirometric criteria based on the ratio of FEV<sub>1</sub>/FVC.<h4>Research question</h4>Does slow vital capacity (SVC) instead of FVC increase the sensitivity of spirometry to identify patients with early or mild obstructive lung disease?<h4>Study design and methods</h4>We included 854 current and former smokers from the Subpopulations and Intermediate Outcome Measures in COPD Study cohort with a postbronchodilator FEV<sub>1</sub>/FVC ≥ 0.7 and FEV<sub>1</sub> % predicted of ≥ 80% at enrollment. We compared baseline characteristics, chest CT scan features, exacerbations, and progression to COPD (postbronchodilator FEV<sub>1</sub>/FVC, < 0.7) during the follow-up period between 734 participants with "],"journal":["Chest"],"pubmed_title":["Ratio of FEV<sub>1</sub>/Slow Vital Capacity of < 0.7 Is Associated With Clinical, Functional, and Radiologic Features of Obstructive Lung Disease in Smokers With Preserved Lung Function."],"pmcid":["PMC8295909"],"funding_grant_id":["P30 ES005605","T32 HL007106","R01 HL151421","U01 HL137880","HHSN268200900015C","HHSN268200900016C","I01 CX000911","HHSN268200900017C","HHSN268200900018C","HHSN268200900019C","U24 HL141762","R01 HL122438","K24 HL138188","KL2 TR001882","HHSN268200900020C","HHSN268200900013C","TL1 TR001883","HHSN268200900014C","K24 HL137013","K23 HL133438","R21 EB027891","R01 HL125432"],"pubmed_authors":["Krishnan JA","Bhakta NR","Hansel NN","Buhr RG","Fortis S","Barr RG","Dolezal B","O'Neal WK","Han MK","Drummond MB","Bhatt SP","Labaki WW","Paine R","Tashkin D","Kanner RE","Bowler RP","Criner G","Hoffman EA","Woodruff P","Comellas AP","Curtis JL","Cooper CB","Ronish B","Ortega VE","Hoesterey D","Kim V","Barjaktarevic I","Dransfield M","Couper D","Arjomandi M","Kaner RJ","Martinez F"],"additional_accession":[]},"is_claimable":false,"name":"Ratio of FEV<sub>1</sub>/Slow Vital Capacity of < 0.7 Is Associated With Clinical, Functional, and Radiologic Features of Obstructive Lung Disease in Smokers With Preserved Lung Function.","description":"<h4>Background</h4>Mild expiratory flow limitation may not be recognized using traditional spirometric criteria based on the ratio of FEV<sub>1</sub>/FVC.<h4>Research question</h4>Does slow vital capacity (SVC) instead of FVC increase the sensitivity of spirometry to identify patients with early or mild obstructive lung disease?<h4>Study design and methods</h4>We included 854 current and former smokers from the Subpopulations and Intermediate Outcome Measures in COPD Study cohort with a postbronchodilator FEV<sub>1</sub>/FVC ≥ 0.7 and FEV<sub>1</sub> % predicted of ≥ 80% at enrollment. We compared baseline characteristics, chest CT scan features, exacerbations, and progression to COPD (postbronchodilator FEV<sub>1</sub>/FVC, < 0.7) during the follow-up period between 734 participants with ","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Jul","modification":"2025-05-29T20:04:46.483Z","creation":"2022-07-10T12:30:19.514Z"},"accession":"S-EPMC8295909","cross_references":{"pubmed":["33539837"],"doi":["10.1016/j.chest.2021.01.067"]}}