biostudies-literatureFortis SNCATS NIH HHSCOPD FoundationNIBIB NIH HHSNIEHS NIH HHSNHLBI NIH HHSNational Institutes of HealthCSRD VA94-103https://www.ebi.ac.uk/biostudies/studies/S-EPMC8295909biostudies-literatureUnknown160(1)<h4>Background</h4>Mild expiratory flow limitation may not be recognized using traditional spirometric criteria based on the ratio of FEV₁/FVC.<h4>Research question</h4>Does slow vital capacity (SVC) instead of FVC increase the sensitivity of spirometry to identify patients with early or mild obstructive lung disease?<h4>Study design and methods</h4>We included 854 current and former smokers from the Subpopulations and Intermediate Outcome Measures in COPD Study cohort with a postbronchodilator FEV₁/FVC ≥ 0.7 and FEV₁ % predicted of ≥ 80% at enrollment. We compared baseline characteristics, chest CT scan features, exacerbations, and progression to COPD (postbronchodilator FEV₁/FVC, < 0.7) during the follow-up period between 734 participants with ChestRatio of FEV₁/Slow Vital Capacity of < 0.7 Is Associated With Clinical, Functional, and Radiologic Features of Obstructive Lung Disease in Smokers With Preserved Lung Function.PMC8295909P30 ES005605T32 HL007106R01 HL151421U01 HL137880HHSN268200900015CHHSN268200900016CI01 CX000911HHSN268200900017CHHSN268200900018CHHSN268200900019CU24 HL141762R01 HL122438K24 HL138188KL2 TR001882HHSN268200900020CHHSN268200900013CTL1 TR001883HHSN268200900014CK24 HL137013K23 HL133438R21 EB027891R01 HL125432Krishnan JABhakta NRHansel NNBuhr RGFortis SBarr RGDolezal BO'Neal WKHan MKDrummond MBBhatt SPLabaki WWPaine RTashkin DKanner REBowler RPCriner GHoffman EAWoodruff PComellas APCurtis JLCooper CBRonish BOrtega VEHoesterey DKim VBarjaktarevic IDransfield MCouper DArjomandi MKaner RJMartinez FfalseRatio of FEV₁/Slow Vital Capacity of < 0.7 Is Associated With Clinical, Functional, and Radiologic Features of Obstructive Lung Disease in Smokers With Preserved Lung Function.<h4>Background</h4>Mild expiratory flow limitation may not be recognized using traditional spirometric criteria based on the ratio of FEV₁/FVC.<h4>Research question</h4>Does slow vital capacity (SVC) instead of FVC increase the sensitivity of spirometry to identify patients with early or mild obstructive lung disease?<h4>Study design and methods</h4>We included 854 current and former smokers from the Subpopulations and Intermediate Outcome Measures in COPD Study cohort with a postbronchodilator FEV₁/FVC ≥ 0.7 and FEV₁ % predicted of ≥ 80% at enrollment. We compared baseline characteristics, chest CT scan features, exacerbations, and progression to COPD (postbronchodilator FEV₁/FVC, < 0.7) during the follow-up period between 734 participants with 2021-01-01T00:00:00Z2021 Jul2025-05-29T20:04:46.483Z2022-07-10T12:30:19.514ZS-EPMC82959093353983710.1016/j.chest.2021.01.067