biostudies-literatureKorenstein DNCATS NIH HHSNIA NIH HHSNational Cancer InstituteNCI NIH HHSNational Institute on Aging2105-2110https://www.ebi.ac.uk/biostudies/studies/S-EPMC8298733biostudies-literatureUnknown36(7)Rigorous evidence about the broad range of harms that might be experienced by a patient in the course of testing and treatment is sparse. We aimed to generate recommendations for how researchers might more comprehensively evaluate potential harms of healthcare interventions, to allow clinicians and patients to better include this evidence in clinical decision-making. We propose seven domains of harms of tests and treatments that are relevant to patients: (1) physical impairment, (2) psychological distress, (3) social disruption, (4) disruption in connection to healthcare, (5) labeling, (6) financial impact, and (7) treatment burden. These domains will include a range of severity of harms and variation in timing after testing or treatment, attributable to the service itself or a resulting cJournal of general internal medicineTo Expand the Evidence Base About Harms from Tests and Treatments.PMC8298733K24 AG049036P30 CA008748P30 CA008748-50UL1 TR001863K24 AG049036-01A1Elshaug AGHarris RMorgan DJCho HJSegal JBRoss JSKorenstein DCooper RJfalseTo Expand the Evidence Base About Harms from Tests and Treatments.Rigorous evidence about the broad range of harms that might be experienced by a patient in the course of testing and treatment is sparse. We aimed to generate recommendations for how researchers might more comprehensively evaluate potential harms of healthcare interventions, to allow clinicians and patients to better include this evidence in clinical decision-making. We propose seven domains of harms of tests and treatments that are relevant to patients: (1) physical impairment, (2) psychological distress, (3) social disruption, (4) disruption in connection to healthcare, (5) labeling, (6) financial impact, and (7) treatment burden. These domains will include a range of severity of harms and variation in timing after testing or treatment, attributable to the service itself or a resulting c2021-01-01T00:00:00Z2021 Jul2025-04-22T21:55:35.806Z2022-07-11T05:19:02.456ZS-EPMC82987333347992810.1007/s11606-021-06597-9