{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Doherty C"],"funding":["NCATS NIH HHS","NINDS NIH HHS"],"pagination":["131-136"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8299517"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["94"],"pubmed_abstract":["<h4>Objective</h4>The objective of this study was to determine whether three common genetic polymorphisms [apolipoprotein (APOE) ε4 (rs42938 and rs7412), brain derived neurotrophic factor (BDNF) Met (rs6265), and catechol-O-methyltransferase (COMT) Val (rs4680)] are associated with increased psychiatric symptomatology in individuals with pharmacoresistant epilepsy.<h4>Methods</h4>One hundred forty-eight adults (M<sub>age</sub> = 38 years; 53% female) with refractory epilepsy completed self-report measures of mood, anxiety, and/or personality/psychopathology. Mann-Whitney U, t-tests, and Fisher's exact tests were used to determine if APOE4, BDNF Val66Met, or COMT Val158Met are associated with increased psychiatric symptomatology in people with epilepsy.<h4>Results</h4>As a group, BDNF Met carriers reported greater symptoms of depression on the Personality Assessment Inventory (PAI) than those without a Met allele (p = 0.004); COMT Val carriers reported greater symptoms on the PAI Schizophrenia (p = 0.007), Antisocial Features (p = 0.04), and Alcohol Problems (p = 0.03) scales than noncarriers. On the individual level, a significantly greater proportion of BDNF Met carriers demonstrated elevated PAI Depression scores compared to those without a Met allele (p = 0.046). There was also a larger proportion of COMT Val carriers with elevated PAI Anxiety scores as compared to those without a Val allele (p = 0.036).<h4>Significance</h4>This retrospective cross-sectional study provides preliminary evidence for a genetic basis of psychiatric comorbidities in epilepsy and suggests that BDNF and COMT may play an important role in the pathophysiology of mental health problems in this vulnerable population."],"journal":["Epilepsy & behavior : E&B"],"pubmed_title":["BDNF and COMT, but not APOE, alleles are associated with psychiatric symptoms in refractory epilepsy."],"pmcid":["PMC8299517"],"funding_grant_id":["KL2 TR000440","UL1 TR000439","K23 NS091344"],"pubmed_authors":["Busch RM","Altemus JB","Hogue O","Floden DP","Doherty C","Najm IM","Eng C"],"additional_accession":[]},"is_claimable":false,"name":"BDNF and COMT, but not APOE, alleles are associated with psychiatric symptoms in refractory epilepsy.","description":"<h4>Objective</h4>The objective of this study was to determine whether three common genetic polymorphisms [apolipoprotein (APOE) ε4 (rs42938 and rs7412), brain derived neurotrophic factor (BDNF) Met (rs6265), and catechol-O-methyltransferase (COMT) Val (rs4680)] are associated with increased psychiatric symptomatology in individuals with pharmacoresistant epilepsy.<h4>Methods</h4>One hundred forty-eight adults (M<sub>age</sub> = 38 years; 53% female) with refractory epilepsy completed self-report measures of mood, anxiety, and/or personality/psychopathology. Mann-Whitney U, t-tests, and Fisher's exact tests were used to determine if APOE4, BDNF Val66Met, or COMT Val158Met are associated with increased psychiatric symptomatology in people with epilepsy.<h4>Results</h4>As a group, BDNF Met carriers reported greater symptoms of depression on the Personality Assessment Inventory (PAI) than those without a Met allele (p = 0.004); COMT Val carriers reported greater symptoms on the PAI Schizophrenia (p = 0.007), Antisocial Features (p = 0.04), and Alcohol Problems (p = 0.03) scales than noncarriers. On the individual level, a significantly greater proportion of BDNF Met carriers demonstrated elevated PAI Depression scores compared to those without a Met allele (p = 0.046). There was also a larger proportion of COMT Val carriers with elevated PAI Anxiety scores as compared to those without a Val allele (p = 0.036).<h4>Significance</h4>This retrospective cross-sectional study provides preliminary evidence for a genetic basis of psychiatric comorbidities in epilepsy and suggests that BDNF and COMT may play an important role in the pathophysiology of mental health problems in this vulnerable population.","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 May","modification":"2022-02-10T22:42:36.374Z","creation":"2022-02-10T22:42:36.374Z"},"accession":"S-EPMC8299517","cross_references":{"pubmed":["30909076"],"doi":["10.1016/j.yebeh.2019.02.032"]}}