biostudies-literatureUnknown10(7)Babylon LMitochondrial dysfunction represents a hallmark of both brain aging and age-related neurodegenerative disorders including Alzheimer disease (AD). AD-related mitochondrial dysfunction is characterized by an impaired electron transport chain (ETC), subsequent decreased adenosine triphoshpate (ATP) levels, and elevated generation of reactive oxygen species (ROS). The bioactive citrus flavanone hesperetin (Hst) is known to modulate inflammatory response, to function as an antioxidant, and to provide neuroprotective properties. The efficacy in improving mitochondrial dysfunction of Hst nanocrystals (HstN) with increased bioavailability has not yet been investigated. Human SH-SY5Y cells harboring neuronal amyloid precursor protein (APP695) acted as a model for the initial phase of AD. MOCK-transAntioxidants (Basel, Switzerland)1003https://www.ebi.ac.uk/biostudies/studies/S-EPMC8300699biostudies-literatureHesperetin Nanocrystals Improve Mitochondrial Function in a Cell Model of Early Alzheimer Disease.PMC8300699Grewal RBabylon LKeck CMEckert GPStahr PLEckert RWfalseHesperetin Nanocrystals Improve Mitochondrial Function in a Cell Model of Early Alzheimer Disease.Mitochondrial dysfunction represents a hallmark of both brain aging and age-related neurodegenerative disorders including Alzheimer disease (AD). AD-related mitochondrial dysfunction is characterized by an impaired electron transport chain (ETC), subsequent decreased adenosine triphoshpate (ATP) levels, and elevated generation of reactive oxygen species (ROS). The bioactive citrus flavanone hesperetin (Hst) is known to modulate inflammatory response, to function as an antioxidant, and to provide neuroprotective properties. The efficacy in improving mitochondrial dysfunction of Hst nanocrystals (HstN) with increased bioavailability has not yet been investigated. Human SH-SY5Y cells harboring neuronal amyloid precursor protein (APP695) acted as a model for the initial phase of AD. MOCK-trans2021-01-01T00:00:00Z2021 Jun2025-04-18T19:12:32.01Z2022-02-10T22:42:51.897ZS-EPMC83006993420154410.3390/antiox10071003