{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["10(7)"],"submitter":["De Santis S"],"pubmed_abstract":["Extra virgin olive oil (EVOO) represents one of the most important health-promoting foods whose antioxidant and anti-inflammatory activities are mainly associated to its polyphenols content. To date, studies exploring the effect of EVOO polyphenols on dendritic cells (DCs), acting as a crosstalk between the innate and the adaptive immune response, are scanty. Therefore, we studied the ability of three EVOO extracts (cv. Coratina, Cima di Mola/Coratina, and Casaliva), characterized by different polyphenols amount, to regulate DCs maturation in resting conditions or after an inflammatory stimulus. Cima di Mola/Coratina and Casaliva extracts were demonstrated to be the most effective in modulating DCs toward an anti-inflammatory profile by reduction of TNF and IL-6 secretion and CD86 expressi"],"journal":["Antioxidants (Basel, Switzerland)"],"pagination":["1016"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8300824"],"repository":["biostudies-literature"],"pubmed_title":["Extra Virgin Olive Oil Extracts Modulate the Inflammatory Ability of Murine Dendritic Cells Based on Their Polyphenols Pattern: Correlation between Chemical Composition and Biological Function."],"pmcid":["PMC8300824"],"pubmed_authors":["Crupi P","Curci F","Franchini C","Chieppa M","Verna G","Faienza MF","Clodoveo ML","Corbo F","Liso M","Milani G","Moschetta A","De Santis S"],"additional_accession":[]},"is_claimable":false,"name":"Extra Virgin Olive Oil Extracts Modulate the Inflammatory Ability of Murine Dendritic Cells Based on Their Polyphenols Pattern: Correlation between Chemical Composition and Biological Function.","description":"Extra virgin olive oil (EVOO) represents one of the most important health-promoting foods whose antioxidant and anti-inflammatory activities are mainly associated to its polyphenols content. To date, studies exploring the effect of EVOO polyphenols on dendritic cells (DCs), acting as a crosstalk between the innate and the adaptive immune response, are scanty. Therefore, we studied the ability of three EVOO extracts (cv. Coratina, Cima di Mola/Coratina, and Casaliva), characterized by different polyphenols amount, to regulate DCs maturation in resting conditions or after an inflammatory stimulus. Cima di Mola/Coratina and Casaliva extracts were demonstrated to be the most effective in modulating DCs toward an anti-inflammatory profile by reduction of TNF and IL-6 secretion and CD86 expressi","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Jun","modification":"2025-05-18T11:04:42.094Z","creation":"2025-05-18T11:04:42.094Z"},"accession":"S-EPMC8300824","cross_references":{"pubmed":["34202671"],"doi":["10.3390/antiox10071016"]}}