{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Amor Lopez A"],"funding":["Fundación Bancaria Caixa d'Estalvis i Pensions de Barcelona","Fundación Fero","Ministerio de Economía, Industria y Competitividad, Gobierno de España","Fundación Bancaria Caixa d'Estalvis i Pensions de Barcelona","Fundación Científica Asociación Española Contra el Cáncer"],"pagination":["7406"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8303474"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["22(14)"],"pubmed_abstract":["Several studies have demonstrated that melanoma-derived extracellular vesicles (EVs) are involved in lymph node metastasis; however, the molecular mechanisms involved are not completely defined. Here, we found that EMILIN-1 is proteolyzed and secreted in small EVs (sEVs) as a novel mechanism to reduce its intracellular levels favoring metastasis in mouse melanoma lymph node metastatic cells. Interestingly, we observed that EMILIN-1 has intrinsic tumor and metastasis suppressive-like properties reducing effective migration, cell viability, primary tumor growth, and metastasis. Overall, our analysis suggests that the inactivation of EMILIN-1 by proteolysis and secretion in sEVs reduce its intrinsic tumor suppressive activities in melanoma favoring tumor progression and metastasis."],"journal":["International journal of molecular sciences"],"pubmed_title":["Inactivation of EMILIN-1 by Proteolysis and Secretion in Small Extracellular Vesicles Favors Melanoma Progression and Metastasis."],"pmcid":["PMC8303474"],"funding_grant_id":["N/A","SAF2014-54541-R"],"pubmed_authors":["Recio JA","Al-Shahrour F","Spessotto P","Mazariegos MS","Capuano A","Ximenez-Embun P","Munoz J","Hergueta-Redondo M","Doliana R","Megias D","Peinado H","Amor Lopez A","Munoz E"],"additional_accession":[]},"is_claimable":false,"name":"Inactivation of EMILIN-1 by Proteolysis and Secretion in Small Extracellular Vesicles Favors Melanoma Progression and Metastasis.","description":"Several studies have demonstrated that melanoma-derived extracellular vesicles (EVs) are involved in lymph node metastasis; however, the molecular mechanisms involved are not completely defined. Here, we found that EMILIN-1 is proteolyzed and secreted in small EVs (sEVs) as a novel mechanism to reduce its intracellular levels favoring metastasis in mouse melanoma lymph node metastatic cells. Interestingly, we observed that EMILIN-1 has intrinsic tumor and metastasis suppressive-like properties reducing effective migration, cell viability, primary tumor growth, and metastasis. Overall, our analysis suggests that the inactivation of EMILIN-1 by proteolysis and secretion in sEVs reduce its intrinsic tumor suppressive activities in melanoma favoring tumor progression and metastasis.","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Jul","modification":"2026-05-01T03:06:47.106Z","creation":"2022-02-11T00:11:07.979Z"},"accession":"S-EPMC8303474","cross_references":{"pubmed":["34299025"],"doi":["10.3390/ijms22147406"]}}