{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Bamodu OA"],"funding":["Teh-Tzer Study Group for Human Medical Research Foundation (TMRF)"],"pagination":["3478"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8303483"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(14)"],"pubmed_abstract":["<i>Background</i>: Testosterone plays a critical role in prostate development and pathology. However, the impact of the molecular interplay between testosterone-associated genes on therapy response and susceptibility to disease relapse in PCa patients remains underexplored. <i>Objective</i>: This study investigated the role of dysregulated or aberrantly expressed testosterone-associated genes in the enhanced dissemination, phenoconversion, and therapy response of treatment-resistant advanced or recurrent PCa. <i>Methods:</i> Employing a combination of multi-omics big data analyses, in vitro, ex vivo, and in vivo assays, we assessed the probable roles of HSD17B2, HSD17B3, SHBG, and SRD5A1-mediated testosterone metabolism in the progression, therapy response, and prognosis of advanced or cas"],"journal":["Cancers"],"pubmed_title":["Differential but Concerted Expression of HSD17B2, HSD17B3, SHBG and SRD5A1 Testosterone Tetrad Modulate Therapy Response and Susceptibility to Disease Relapse in Patients with Prostate Cancer."],"pmcid":["PMC8303483"],"funding_grant_id":["A1091044"],"pubmed_authors":["Chen KC","Wu WL","Lin CD","Hu SW","Wang YH","Wu CC","Bamodu OA","Tzou KY"],"additional_accession":[]},"is_claimable":false,"name":"Differential but Concerted Expression of HSD17B2, HSD17B3, SHBG and SRD5A1 Testosterone Tetrad Modulate Therapy Response and Susceptibility to Disease Relapse in Patients with Prostate Cancer.","description":"<i>Background</i>: Testosterone plays a critical role in prostate development and pathology. However, the impact of the molecular interplay between testosterone-associated genes on therapy response and susceptibility to disease relapse in PCa patients remains underexplored. <i>Objective</i>: This study investigated the role of dysregulated or aberrantly expressed testosterone-associated genes in the enhanced dissemination, phenoconversion, and therapy response of treatment-resistant advanced or recurrent PCa. <i>Methods:</i> Employing a combination of multi-omics big data analyses, in vitro, ex vivo, and in vivo assays, we assessed the probable roles of HSD17B2, HSD17B3, SHBG, and SRD5A1-mediated testosterone metabolism in the progression, therapy response, and prognosis of advanced or cas","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Jul","modification":"2026-04-08T09:11:05.213Z","creation":"2022-02-11T00:09:01.039Z"},"accession":"S-EPMC8303483","cross_references":{"pubmed":["34298692"],"doi":["10.3390/cancers13143478"]}}