{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Tcheng M"],"funding":["Ontario Institute for Cancer Research","Natural Sciences and Engineering Research Council of Canada","Cancer Research Society","NIDDK NIH HHS","NIAID NIH HHS","National Institutes of Health"],"pagination":["6323-6333"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8312404"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(14)"],"pubmed_abstract":["Avocado consumption is associated with numerous health benefits. Avocadyne is a terminally unsaturated, 17-carbon long acetogenin found almost exclusively in avocados with noted anti-leukemia and anti-viral properties. In this study, specific structural features such as the terminal triple bond, odd number of carbons, and stereochemistry are shown to be critical to its ability to suppress mitochondrial fatty acid oxidation and impart selective activity in vitro and in vivo. Together, this is the first study to conduct a structure-activity analysis on avocadyne and outline the chemical moieties critical to fatty acid oxidation suppression."],"journal":["Food & function"],"pubmed_title":["Structure-activity relationship of avocadyne."],"pmcid":["PMC8312404"],"funding_grant_id":["R01 DK078775","R01-DK78755","R01 AI154860","R01 DK109907"],"pubmed_authors":["Rea KA","D'Alessandro A","Akhtar TA","Spagnuolo PA","Vockley J","Smith RW","O'Doherty GA","Cunha VLS","Ahmed N","Liu X","Tcheng M","Minden MD","Lowary TL"],"additional_accession":[]},"is_claimable":false,"name":"Structure-activity relationship of avocadyne.","description":"Avocado consumption is associated with numerous health benefits. Avocadyne is a terminally unsaturated, 17-carbon long acetogenin found almost exclusively in avocados with noted anti-leukemia and anti-viral properties. In this study, specific structural features such as the terminal triple bond, odd number of carbons, and stereochemistry are shown to be critical to its ability to suppress mitochondrial fatty acid oxidation and impart selective activity in vitro and in vivo. Together, this is the first study to conduct a structure-activity analysis on avocadyne and outline the chemical moieties critical to fatty acid oxidation suppression.","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Jul","modification":"2025-05-18T12:58:51.013Z","creation":"2025-05-18T12:58:51.013Z"},"accession":"S-EPMC8312404","cross_references":{"pubmed":["34095930"],"doi":["10.1039/d1fo00693b"]}}