{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["78(9)"],"submitter":["Albers GW"],"pubmed_abstract":["<h4>Importance</h4>The optimal imaging approach for identifying patients who may benefit from endovascular thrombectomy (EVT) beyond 6 hours after they were last known well is unclear. Six randomized clinical trials (RCTs) have evaluated the efficacy of EVT vs standard medical care among patients with ischemic stroke.<h4>Objective</h4>To assess the benefits of EVT among patients with 3 baseline imaging profiles using a pooled analysis of RCTs.<h4>Data sources</h4>The AURORA (Analysis of Pooled Data from Randomized Studies of Thrombectomy More Than 6 Hours After Last Known Well) Collaboration pooled patient-level data from the included clinical trials.<h4>Study selection</h4>An online database search identified RCTs of endovascular stroke therapy published between January 1, 2010, and March"],"journal":["JAMA neurology"],"pagination":["1064-1071"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8314176"],"repository":["biostudies-literature"],"pubmed_title":["Assessment of Optimal Patient Selection for Endovascular Thrombectomy Beyond 6 Hours After Symptom Onset: A Pooled Analysis of the AURORA Database."],"pmcid":["PMC8314176"],"pubmed_authors":["Demchuk AM","Shuaib A","Sila CA","Marks MP","Millan M","Christensen S","Martins SO","McTaggart RA","Cognard C","Heit JJ","Lansberg MG","Haussen DC","Bhuva P","Goyal M","Turk AS","Liebeskind DS","AURORA Investigators","Kim-Tenser M","Hill M","Hassan AE","Bonafe A","Nogueira RG","Rebello LC","Yavagal DR","Budzik RF","Tsai JP","Jadhav AP","Ribo M","Hanel RA","Ortega-Gutierrez S","Torbey MT","Albers GW","Leslie-Mazwi T","Jovin TG","Brown S"],"additional_accession":[]},"is_claimable":false,"name":"Assessment of Optimal Patient Selection for Endovascular Thrombectomy Beyond 6 Hours After Symptom Onset: A Pooled Analysis of the AURORA Database.","description":"<h4>Importance</h4>The optimal imaging approach for identifying patients who may benefit from endovascular thrombectomy (EVT) beyond 6 hours after they were last known well is unclear. Six randomized clinical trials (RCTs) have evaluated the efficacy of EVT vs standard medical care among patients with ischemic stroke.<h4>Objective</h4>To assess the benefits of EVT among patients with 3 baseline imaging profiles using a pooled analysis of RCTs.<h4>Data sources</h4>The AURORA (Analysis of Pooled Data from Randomized Studies of Thrombectomy More Than 6 Hours After Last Known Well) Collaboration pooled patient-level data from the included clinical trials.<h4>Study selection</h4>An online database search identified RCTs of endovascular stroke therapy published between January 1, 2010, and March","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Sep","modification":"2026-05-08T02:35:04.626Z","creation":"2024-11-08T16:46:57.169Z"},"accession":"S-EPMC8314176","cross_references":{"pubmed":["34309619"],"doi":["10.1001/jamaneurol.2021.2319"]}}