biostudies-literatureUnknown78(9)Albers GW<h4>Importance</h4>The optimal imaging approach for identifying patients who may benefit from endovascular thrombectomy (EVT) beyond 6 hours after they were last known well is unclear. Six randomized clinical trials (RCTs) have evaluated the efficacy of EVT vs standard medical care among patients with ischemic stroke.<h4>Objective</h4>To assess the benefits of EVT among patients with 3 baseline imaging profiles using a pooled analysis of RCTs.<h4>Data sources</h4>The AURORA (Analysis of Pooled Data from Randomized Studies of Thrombectomy More Than 6 Hours After Last Known Well) Collaboration pooled patient-level data from the included clinical trials.<h4>Study selection</h4>An online database search identified RCTs of endovascular stroke therapy published between January 1, 2010, and MarchJAMA neurology1064-1071https://www.ebi.ac.uk/biostudies/studies/S-EPMC8314176biostudies-literatureAssessment of Optimal Patient Selection for Endovascular Thrombectomy Beyond 6 Hours After Symptom Onset: A Pooled Analysis of the AURORA Database.PMC8314176Demchuk AMShuaib ASila CAMarks MPMillan MChristensen SMartins SOMcTaggart RACognard CHeit JJLansberg MGHaussen DCBhuva PGoyal MTurk ASLiebeskind DSAURORA InvestigatorsKim-Tenser MHill MHassan AEBonafe ANogueira RGRebello LCYavagal DRBudzik RFTsai JPJadhav APRibo MHanel RAOrtega-Gutierrez STorbey MTAlbers GWLeslie-Mazwi TJovin TGBrown SfalseAssessment of Optimal Patient Selection for Endovascular Thrombectomy Beyond 6 Hours After Symptom Onset: A Pooled Analysis of the AURORA Database.<h4>Importance</h4>The optimal imaging approach for identifying patients who may benefit from endovascular thrombectomy (EVT) beyond 6 hours after they were last known well is unclear. Six randomized clinical trials (RCTs) have evaluated the efficacy of EVT vs standard medical care among patients with ischemic stroke.<h4>Objective</h4>To assess the benefits of EVT among patients with 3 baseline imaging profiles using a pooled analysis of RCTs.<h4>Data sources</h4>The AURORA (Analysis of Pooled Data from Randomized Studies of Thrombectomy More Than 6 Hours After Last Known Well) Collaboration pooled patient-level data from the included clinical trials.<h4>Study selection</h4>An online database search identified RCTs of endovascular stroke therapy published between January 1, 2010, and March2021-01-01T00:00:00Z2021 Sep2026-05-08T02:35:04.626Z2024-11-08T16:46:57.169ZS-EPMC83141763430961910.1001/jamaneurol.2021.2319