biostudies-literatureBentley CAOUK&amp;I FoundationNational Institute for Health Research - Surgical Reconstruction and Microbiology Research CentreCancer Research UKQueen Elizabeth Hospital Birmingham CharityMedical Research Councile040823https://www.ebi.ac.uk/biostudies/studies/S-EPMC8314713biostudies-literatureUnknown11(7)<h4>Introduction</h4>The improvements in short-term outcome after severe trauma achieved through early resuscitation and acute care can be offset over the following weeks by an acute systemic inflammatory response with immuneparesis leading to infection, multiorgan dysfunction/multiorgan failure (MOF) and death. Serum levels of the androgen precursor dehydroepiandrosterone (DHEA) and its sulfate ester DHEAS, steroids with immune-enhancing activity, are low after traumatic injury at a time when patients are catabolic and immunosuppressed. Addressing this deficit and restoring the DHEA(S) ratio to cortisol may provide a range of physiological benefits, including immune modulatory effects.<h4>Objective</h4>Our primary objective is to establish a dose suitable for DHEA supplementation in patieBMJ openA prospective, phase II, single-centre, cross-sectional, randomised study investigating Dehydroepiandrosterone supplementation and its Profile in Trauma: ADaPT.PMC8314713n/a25354MR/K00414X/1MR/P021220/1Shaheen FBentley CCarrera RFoster MAToman EGreig CABarton DErmogenous CGilligan LCHomer VHazeldine JArlt WTaylor AEYakoub KMDesai APotter CLord JMYoung KMcGee KBrock KAthwal ASur GfalseA prospective, phase II, single-centre, cross-sectional, randomised study investigating Dehydroepiandrosterone supplementation and its Profile in Trauma: ADaPT.<h4>Introduction</h4>The improvements in short-term outcome after severe trauma achieved through early resuscitation and acute care can be offset over the following weeks by an acute systemic inflammatory response with immuneparesis leading to infection, multiorgan dysfunction/multiorgan failure (MOF) and death. Serum levels of the androgen precursor dehydroepiandrosterone (DHEA) and its sulfate ester DHEAS, steroids with immune-enhancing activity, are low after traumatic injury at a time when patients are catabolic and immunosuppressed. Addressing this deficit and restoring the DHEA(S) ratio to cortisol may provide a range of physiological benefits, including immune modulatory effects.<h4>Objective</h4>Our primary objective is to establish a dose suitable for DHEA supplementation in patie2021-01-01T00:00:00Z2021 Jul2026-05-08T10:04:57.442Z2022-02-11T07:10:31.779ZS-EPMC83147133431219010.1136/bmjopen-2020-040823