biostudies-literatureGBD 2019 CollaboratorsNIA NIH HHSFIC NIH HHSNHGRI NIH HHSWellcome Truste12200https://www.ebi.ac.uk/biostudies/studies/S-EPMC8315276biostudies-literatureUnknown7(1)<h4>Introduction</h4>Dementia is currently one of the leading causes of mortality globally, and mortality due to dementia will likely increase in the future along with corresponding increases in population growth and population aging. However, large inconsistencies in coding practices in vital registration systems over time and between countries complicate the estimation of global dementia mortality.<h4>Methods</h4>We meta-analyzed the excess risk of death in those with dementia and multiplied these estimates by the proportion of dementia deaths occurring in those with severe, end-stage disease to calculate the total number of deaths that could be attributed to dementia.<h4>Results</h4>We estimated that there were 1.62 million (95% uncertainty interval [UI]: 0.41-4.21) deaths globally due Alzheimer's & dementia (New York, N. Y.)Global mortality from dementia: Application of a new method and results from the Global Burden of Disease Study 2019.PMC8315276U01 HG010273U01 AG016976K43 TW010716202912R01 AG056477Leonardi MBirhan TAEdvardsson DBaune BTManjunatha NCernigliaro AOgbo FAMokdad AHRashedi VRam PBanach MHwang BFHankey GJVelazquez DZTsegaye GWManafi NBiswas ASahathevan RBrayne CGolechha MGhashghaee AWang YPBarboza MAAmin HIMAyano GKomaki HMeretoja AHaro JMGebregzabiher KZKoyanagi AAbd-Allah FWei JNichols EGupta RChu DTCherbuin NKarch AToroudi HPZhang ZJMenezes RGDandona RMohapatra ASilva JPKisa SKukull WAMurray CJLIwagami MKisa APham HQHassan AJha RPAnsari ISpurlock EERana JVos TMulugeta ARawaf DLTovani-Palone MRMohebi FFernandes ESchmidt MISchiavolin SKengne APDandona LFilip ITravillian RSHachinski VPeterson CBSachdev PSHouseh MKivimaki MNayak VCGholamian AOtstavnov SSBiondi ADouiri ALiu XUsman MSWeiss JShin JITran BXHeidari-Soureshjani RMetekiya WMRawaf SSahebkar ABolla SRGaidhane SPhillips MRReinig NNguyen SHTripathi MRahim FCarvalho FCatala-Lopez FPathak MSiddiqi TJKasa ASMisganaw ATBijani AKalani RAkinyemi ROAbosetugn AENagaraja SBPottoo FHShahid IAbrha WAIlic MDSingh JAYamagishi KEl-Jaafary SIKandel HVacante MYadollahpour AYonemoto NLogroscino GOwolabi MORezaei NShiri RSzoeke CEICerin ESayyah MAlipour VOstojic SMAshraf-Ganjouei AHeidari GThakur BVlassov VBrenner HAlahdab FNaveed MFischer FLorkowski STaddele BWIrvani SSNSaylan MZadey SWimo AMossie TBAbu-Gharbieh ENguyen HLTDai XWeldemariam AHBurkart KTabares-Seisdedos RForooshani ZSDKumar GAMerkin ANunez-Samudio VRaggi AIlic IMOrru HMehndiratta MMRadfar ACastro-de-Araujo LFSGBD 2019 CollaboratorsAvan AEskandarieh SIso HBurns RAOstroff SMNagel GBoloor AWu CKumar MBhagavathula ASMohammad YHussain RDagnew BBabar ZURobinson SRShigematsu MVenketasubramanian NHay SILoy CTBarker-Collo SLPrada SIAbdoli AFerrara POtstavnov NSattin DSahraian MALim SSBaig AADiaz DVidale SSoheili AEskandari KLandires IArabloo JBhattacharyya KFeigin VLAlanezi FMDuncan BBMohajer BKim YJShaikh MAOlagunju ATChoi JJMondello SKim YEHamidi SRomoli MIbrahim NMPiradov MAGnedovskaya EVLopez ADFereshtehnejad SMThekkePurakkal ASPribadi DRAKandel SNAbualhasan AYeshitila YGfalseGlobal mortality from dementia: Application of a new method and results from the Global Burden of Disease Study 2019.<h4>Introduction</h4>Dementia is currently one of the leading causes of mortality globally, and mortality due to dementia will likely increase in the future along with corresponding increases in population growth and population aging. However, large inconsistencies in coding practices in vital registration systems over time and between countries complicate the estimation of global dementia mortality.<h4>Methods</h4>We meta-analyzed the excess risk of death in those with dementia and multiplied these estimates by the proportion of dementia deaths occurring in those with severe, end-stage disease to calculate the total number of deaths that could be attributed to dementia.<h4>Results</h4>We estimated that there were 1.62 million (95% uncertainty interval [UI]: 0.41-4.21) deaths globally due 2021-01-01T00:00:00Z20212026-03-17T16:06:16.379Z2022-02-11T01:32:37.332ZS-EPMC83152763433713810.1002/trc2.12200