{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Sun PZ"],"funding":["National Institute of Neurological Disorders and Stroke","National Institute of Arthritis and Musculoskeletal and Skin Diseases","Emory University","NINDS NIH HHS","Yerkes National Primate Research Center, Emory University","National Institutes of Health","NIAMS NIH HHS","NIH HHS"],"pagination":["107022"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8316384"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["329"],"pubmed_abstract":["Chemical exchange saturation transfer (CEST) MRI depends not only on the labile proton concentration and exchange rate but also on relaxation rates, particularly T<sub>1</sub> relaxation time. However, T<sub>1</sub> normalization has shown to be not straightforward under non-steady-state conditions and in the presence of radiofrequency spillover effect. Our study aimed to test if the combined use of the new quasi-steady-state (QUASS) analysis and inverse CEST calculation facilitates T<sub>1</sub> normalization for improved CEST quantification. The CEST signal was simulated with Bloch-McConnell equations, and the apparent CEST, QUASS CEST, and the inverse CEST effects were calculated. T<sub>1</sub>-normalized CEST effects were tested for their specificity to the underlying CEST system (i.e."],"journal":["Journal of magnetic resonance (San Diego, Calif. : 1997)"],"pubmed_title":["Quasi-steady-state chemical exchange saturation transfer (QUASS CEST) MRI analysis enables T<sub>1</sub> normalized CEST quantification - Insight into T<sub>1</sub> contribution to CEST measurement."],"pmcid":["PMC8316384"],"funding_grant_id":["R21AR071529","R21 AR071529","P51 OD011132","R01 NS083654","2R01NS083654","P51OD011132"],"pubmed_authors":["Sun PZ"],"additional_accession":[]},"is_claimable":false,"name":"Quasi-steady-state chemical exchange saturation transfer (QUASS CEST) MRI analysis enables T<sub>1</sub> normalized CEST quantification - Insight into T<sub>1</sub> contribution to CEST measurement.","description":"Chemical exchange saturation transfer (CEST) MRI depends not only on the labile proton concentration and exchange rate but also on relaxation rates, particularly T<sub>1</sub> relaxation time. However, T<sub>1</sub> normalization has shown to be not straightforward under non-steady-state conditions and in the presence of radiofrequency spillover effect. Our study aimed to test if the combined use of the new quasi-steady-state (QUASS) analysis and inverse CEST calculation facilitates T<sub>1</sub> normalization for improved CEST quantification. The CEST signal was simulated with Bloch-McConnell equations, and the apparent CEST, QUASS CEST, and the inverse CEST effects were calculated. T<sub>1</sub>-normalized CEST effects were tested for their specificity to the underlying CEST system (i.e.","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Aug","modification":"2025-04-26T16:34:25.263Z","creation":"2025-04-06T15:13:04.904Z"},"accession":"S-EPMC8316384","cross_references":{"pubmed":["34144360"],"doi":["10.1016/j.jmr.2021.107022"]}}