biostudies-literatureUnknown8Mansour SMG<i>Avian orthoavulavirus</i> 1, formerly known as avian paramyxovirus type-1 (APMV-1), infects more than 250 different species of birds. It causes a broad range of clinical diseases and results in devastating economic impact due to high morbidity and mortality in addition to trade restrictions. The ease of spread has allowed the virus to disseminate worldwide with subjective virulence, which depends on the virus strain and host species. The emergence of new virulent genotypes among global epizootics, including those from Egypt, illustrates the time-to-time genomic alterations that lead to simultaneous evolution of distinct APMV-1 genotypes at different geographic locations across the world. In Egypt, the Newcastle disease was firstly reported in 1947 and continued to occur, despite rigorouFrontiers in veterinary science647462https://www.ebi.ac.uk/biostudies/studies/S-EPMC8320000biostudies-literatureAvian <i>Paramyxovirus</i> Type 1 in Egypt: Epidemiology, Evolutionary Perspective, and Vaccine Approach.PMC8320000Abdien HMFEid AAMHamouda EEElbestawy ARMohamed FFElBakrey RMMansour SMGAbdallah MSIsmail MMfalseAvian <i>Paramyxovirus</i> Type 1 in Egypt: Epidemiology, Evolutionary Perspective, and Vaccine Approach.<i>Avian orthoavulavirus</i> 1, formerly known as avian paramyxovirus type-1 (APMV-1), infects more than 250 different species of birds. It causes a broad range of clinical diseases and results in devastating economic impact due to high morbidity and mortality in addition to trade restrictions. The ease of spread has allowed the virus to disseminate worldwide with subjective virulence, which depends on the virus strain and host species. The emergence of new virulent genotypes among global epizootics, including those from Egypt, illustrates the time-to-time genomic alterations that lead to simultaneous evolution of distinct APMV-1 genotypes at different geographic locations across the world. In Egypt, the Newcastle disease was firstly reported in 1947 and continued to occur, despite rigorou2021-01-01T00:00:00Z20212026-05-08T09:00:59.156Z2022-02-11T02:21:08.354ZS-EPMC83200003433696510.3389/fvets.2021.647462