{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12"],"submitter":["Song Y"],"pubmed_abstract":["Eggplant (<i>Solanum melongena</i> L.) Calyx is a medicinal and edible traditional Chinese medicine with anti-inflammatory, anti-oxidant, and anti-cancer properties. However, the pharmacodynamic components and metabolic characteristics remain unclear. Amide and phenylpropanoid were the two main constituents, and four amides, including <i>n</i>-trans-<i>p</i>-coumaroyltyramine (<b>1</b>), <i>n</i>-trans-<i>p</i>-coumaroyloctopamine (<b>2</b>), <i>n</i>-trans-<i>p</i>-coumaroylnoradrenline (<b>3</b>), <i>n</i>-trans-feruloyloctopamine (<b>4</b>), and a phenylpropanoid neochlorogenic acid (<b>5</b>) were selected. In this study, these five representative compounds showed cytotoxic activities on A549, HCT116, and MCF7 cells. In addition, the metabolites of <b>1-5</b> from the eggplant calyx in"],"journal":["Frontiers in pharmacology"],"pagination":["655008"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8320773"],"repository":["biostudies-literature"],"pubmed_title":["Metabolites Identification of Chemical Constituents From the Eggplant (<i>Solanum melongena</i> L.) Calyx in Rats by UPLC/ESI/qTOF-MS Analysis and Their Cytotoxic Activities."],"pmcid":["PMC8320773"],"pubmed_authors":["Liu Y","Wang Q","Zhang J","Xie M","Mei T","Liang M","Kong S","Ou S","Song Y"],"additional_accession":[]},"is_claimable":false,"name":"Metabolites Identification of Chemical Constituents From the Eggplant (<i>Solanum melongena</i> L.) Calyx in Rats by UPLC/ESI/qTOF-MS Analysis and Their Cytotoxic Activities.","description":"Eggplant (<i>Solanum melongena</i> L.) Calyx is a medicinal and edible traditional Chinese medicine with anti-inflammatory, anti-oxidant, and anti-cancer properties. However, the pharmacodynamic components and metabolic characteristics remain unclear. Amide and phenylpropanoid were the two main constituents, and four amides, including <i>n</i>-trans-<i>p</i>-coumaroyltyramine (<b>1</b>), <i>n</i>-trans-<i>p</i>-coumaroyloctopamine (<b>2</b>), <i>n</i>-trans-<i>p</i>-coumaroylnoradrenline (<b>3</b>), <i>n</i>-trans-feruloyloctopamine (<b>4</b>), and a phenylpropanoid neochlorogenic acid (<b>5</b>) were selected. In this study, these five representative compounds showed cytotoxic activities on A549, HCT116, and MCF7 cells. In addition, the metabolites of <b>1-5</b> from the eggplant calyx in","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021","modification":"2025-04-26T06:39:21.245Z","creation":"2022-02-11T01:41:13.865Z"},"accession":"S-EPMC8320773","cross_references":{"pubmed":["34335243"],"doi":["10.3389/fphar.2021.655008"]}}