biostudies-literatureUnknown12Song YEggplant (<i>Solanum melongena</i> L.) Calyx is a medicinal and edible traditional Chinese medicine with anti-inflammatory, anti-oxidant, and anti-cancer properties. However, the pharmacodynamic components and metabolic characteristics remain unclear. Amide and phenylpropanoid were the two main constituents, and four amides, including <i>n</i>-trans-<i>p</i>-coumaroyltyramine (<b>1</b>), <i>n</i>-trans-<i>p</i>-coumaroyloctopamine (<b>2</b>), <i>n</i>-trans-<i>p</i>-coumaroylnoradrenline (<b>3</b>), <i>n</i>-trans-feruloyloctopamine (<b>4</b>), and a phenylpropanoid neochlorogenic acid (<b>5</b>) were selected. In this study, these five representative compounds showed cytotoxic activities on A549, HCT116, and MCF7 cells. In addition, the metabolites of <b>1-5</b> from the eggplant calyx inFrontiers in pharmacology655008https://www.ebi.ac.uk/biostudies/studies/S-EPMC8320773biostudies-literatureMetabolites Identification of Chemical Constituents From the Eggplant (<i>Solanum melongena</i> L.) Calyx in Rats by UPLC/ESI/qTOF-MS Analysis and Their Cytotoxic Activities.PMC8320773Liu YWang QZhang JXie MMei TLiang MKong SOu SSong YfalseMetabolites Identification of Chemical Constituents From the Eggplant (<i>Solanum melongena</i> L.) Calyx in Rats by UPLC/ESI/qTOF-MS Analysis and Their Cytotoxic Activities.Eggplant (<i>Solanum melongena</i> L.) Calyx is a medicinal and edible traditional Chinese medicine with anti-inflammatory, anti-oxidant, and anti-cancer properties. However, the pharmacodynamic components and metabolic characteristics remain unclear. Amide and phenylpropanoid were the two main constituents, and four amides, including <i>n</i>-trans-<i>p</i>-coumaroyltyramine (<b>1</b>), <i>n</i>-trans-<i>p</i>-coumaroyloctopamine (<b>2</b>), <i>n</i>-trans-<i>p</i>-coumaroylnoradrenline (<b>3</b>), <i>n</i>-trans-feruloyloctopamine (<b>4</b>), and a phenylpropanoid neochlorogenic acid (<b>5</b>) were selected. In this study, these five representative compounds showed cytotoxic activities on A549, HCT116, and MCF7 cells. In addition, the metabolites of <b>1-5</b> from the eggplant calyx in2021-01-01T00:00:00Z20212025-04-26T06:39:21.245Z2022-02-11T01:41:13.865ZS-EPMC83207733433524310.3389/fphar.2021.655008